ArticleBehavioral neuroscience2015
Amphetamine-induced sensitization and reward uncertainty similarly enhance incentive salience for conditioned cues.
Article in Behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?Psychopharmacology · 2026Review
- The effects of reward uncertainty and alcohol intoxication on human sign- and goal-tracking.Psychopharmacology · 2026Article
- Test-retest reliability of the gaze index for sign-tracking and goal-tracking.Behavior research methods · 2026Article
- Article
- Motivation, attention, and uncertainty: insights from animal and human research and implications for addiction.Frontiers in psychology · 2026Review
- The Incentive-Sensitization Theory of Addiction 30 Years On.Annual review of psychology · 2025Review
- Decomposition of Reinforcement Learning Deficits in Disordered Gambling via Drift Diffusion Modeling and Functional Magnetic Resonance Imaging.Computational psychiatry (Cambridge, Mass.) · 2024Article
- Quantifying the instrumental and noninstrumental underpinnings of Pavlovian responding with the Price equation.Psychonomic bulletin & review · 2022Review
- [Neurogenetics of schizophrenia: findings from studies based on data sharing and global partnerships].Der Nervenarzt · 2021Review
- Unpredictability as a modulator of drug self-administration: Relevance for substance-use disorders.Behavioural processes · 2020Review
- Maladaptive consequences of repeated intermittent exposure to uncertainty.Progress in neuro-psychopharmacology & biological psychiatry · 2020Review
- Using rodent models to understand interactions between gambling and substance use.Current opinion in behavioral sciences · 2020Article
- Cued for risk: Evidence for an incentive sensitization framework to explain the interplay between stress and anxiety, substance abuse, and reward uncertainty in disordered gambling behavior.Cognitive, affective & behavioral neuroscience · 2019Review
- Multiple reward-cue contingencies favor expectancy over uncertainty in shaping the reward-cue attentional salience.Psychological research · 2019Article
- Nicotine pre-treatment reduces sensitivity to the interoceptive stimulus effects of commonly abused drugs as assessed with taste conditioning paradigms.Drug and alcohol dependence · 2019Article
- Sign-tracking is an expectancy-mediated behavior that relies on prediction error mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Heterogeneous dopamine signals support distinct features of motivated actions: implications for learning and addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Repeated cocaine exposure dysregulates cognitive control over cue-evoked reward-seeking behavior during Pavlovian-to-instrumental transfer.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Current perspectives on incentive salience and applications to clinical disorders.Current opinion in behavioral sciences · 2018Article
- Ethanol Exposure History and Alcoholic Reward Differentially Alter Dopamine Release in the Nucleus Accumbens to a Reward-Predictive Cue.Alcoholism, clinical and experimental research · 2018Article
Corrections and comments
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4 authors.
Funding
Abstract
Amphetamine and stress can sensitize mesolimbic dopamine-related systems. In Pavlovian autoshaping, repeated exposure to uncertainty of reward prediction can enhance motivated sign-tracking or attraction to a discrete reward-predicting cue (lever-conditioned stimulus; CS+), as well as produce cross-sensitization to amphetamine. However, it remains unknown how amphetamine sensitization or repeated restraint stress interact with uncertainty in controlling CS+ incentive salience attribution reflected in sign-tracking. Here rats were tested in 3 successive phases. First, different groups underwent either induction of amphetamine sensitization or repeated restraint stress, or else were not sensitized or stressed as control groups (either saline injections only, or no stress or injection at all). All next received Pavlovian autoshaping training under either certainty conditions (100% CS-UCS association) or uncertainty conditions (50% CS-UCS association and uncertain reward magnitude). During training, rats were assessed for sign-tracking to the CS+ lever versus goal-tracking to the sucrose dish. Finally, all groups were tested for psychomotor sensitization of locomotion revealed by an amphetamine challenge. Our results confirm that reward uncertainty enhanced sign-tracking attraction toward the predictive CS+ lever, at the expense of goal-tracking. We also reported that amphetamine sensitization promoted sign-tracking even in rats trained under CS-UCS certainty conditions, raising them to sign-tracking levels equivalent to the uncertainty group. Combining amphetamine sensitization and uncertainty conditions did not add together to elevate sign-tracking further above the relatively high levels induced by either manipulation alone. In contrast, repeated restraint stress enhanced subsequent amphetamine-elicited locomotion, but did not enhance CS+ attraction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.