Evidence map›Paper›PMID 26075969›Full record

ArticleJournal of abnormal psychology2015

Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2.

Jessica E Salvatore, Jacquelyn L Meyers, Jia Yan, Fazil Aliev, Jennifer E Lansford, Gregory S Pettit, John E Bates, Kenneth A Dodge, Richard J Rose, Lea Pulkkinen and 2 more

Abstract readTwin Study
In one paragraph

Article in Journal of abnormal psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. FinnTwin12 Cohort: An Updated Review.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Review
  4. Intergenerational continuity in alcohol misuse: Maternal alcohol use disorder and the sequelae of maternal and family functioning.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019
    Article
  5. Article
  6. Article
  7. Article
  8. A genome wide association study of fast beta EEG in families of European ancestry.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
    Article
  9. Genetic influences on adolescent behavior.Neuroscience and biobehavioral reviews · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jessica E SalvatoreDepartment of Psychiatry, Virginia Commonwealth University.
Jacquelyn L MeyersDepartment of Psychiatry, Virginia Commonwealth University.
Jia YanDepartment of Psychiatry, Virginia Commonwealth University.
Fazil AlievDepartment of Psychiatry, Virginia Commonwealth University.
Jennifer E LansfordCenter for Child and Family Policy, Duke University.
Gregory S PettitDepartment of Human Development and Family Studies, Auburn University.
John E BatesDepartment of Psychological and Brain Sciences, Indiana University.
Kenneth A DodgeCenter for Child and Family Policy, Duke University.
Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University.
Lea PulkkinenDepartment of Psychology, University of Jyvaskyla.
Jaakko KaprioDepartment of Public Health, University of Helsinki.
Danielle M DickDepartment of Psychiatry, Virginia Commonwealth University.

Funding

Optimizing Prevention of Costly Adult OutcomesR01DA016903 · NIDA · DUKE UNIVERSITY · PI CROWLEY, DANIEL MAX, DODGE, KENNETH A · 2003 to 2019
$10.2M
The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
ADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9M
HOW CHRONIC CONDUCT PROBLEMS DEVELOPR01MH056961 · NIMH · VANDERBILT UNIVERSITY · PI DODGE, KENNETH A · 1998 to 2008
$1.9M
HOW CHRONIC CONDUCT PROBLEMS DEVELOPR01MH057024 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI BATES, JOHN E · 1998 to 2008
$1.7M
HOW CHRONIC CONDUCT PROBLEMS DEVELOPR01MH057095 · NIMH · AUBURN UNIVERSITY AT AUBURN · PI PETTIT, GREGORY S · 1998 to 2008
$1.5M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Adolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2M
Gene-Environment Interaction for Cannabis Use Disorders in Blacks and Whites in the U.S.K01DA037914 · NIDA · SUNY DOWNSTATE MEDICAL CENTER · PI MEYERS, JACQUELYN LEIGH · 2015 to 2019
$573k
Genetically-informed designs of externalizing behavior and romantic relationshipsF32AA022269 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2013 to 2014
$113k
DEVELOPMENT OF AGGRESSIVE BEHAVIORR01MH042498 · NIMH · VANDERBILT UNIVERSITY · PI DODGE, KENNETH A · 1987 to 1991
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NCCDPHP CDC HHS H13 DP424981NIAAA NIH HHS AA00145NIAAA NIH HHS AA12502NIAAA NIH HHS AA15416NIAAA NIH HHS F32 AA022269NIAAA NIH HHS F32AA022269NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K02AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS L30 AA014504NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R37 AA012502NICHD NIH HHS R01 HD030572NIDA NIH HHS DA016903NIDA NIH HHS K01 DA037914NIDA NIH HHS R01 DA016903NIMH NIH HHS MH057024-07S1NIMH NIH HHS MH56961NIMH NIH HHS MH57024NIMH NIH HHS MH57095NIMH NIH HHS R01 MH042498NIMH NIH HHS R01 MH056961NIMH NIH HHS R01 MH057024NIMH NIH HHS R01 MH057095NIMH NIH HHS T32 MH020030NIMH NIH HHS T32MH20030-14
6 · The paper itself

Abstract

We examine whether parental externalizing behavior has an indirect effect on adolescent externalizing behavior via elevations in life events, and whether this indirect effect is further qualified by an interaction between life events and adolescents' GABRA2 genotype (rs279871). We use data from 2 samples: the Child Development Project (CDP; n = 324) and FinnTwin12 (n = 802). In CDP, repeated measures of life events, mother-reported adolescent externalizing, and teacher-reported adolescent externalizing were used. In FinnTwin12, life events and externalizing were assessed at age 14. Parental externalizing was indexed by measures of antisocial behavior and alcohol problems or alcohol dependence symptoms in both samples. In CDP, parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p ≤ .05). The association between life events and subsequent adolescent externalizing was stronger for adolescents with 0 copies of the G minor allele compared to those with 1 or 2 copies of the minor allele. Parallel moderation trends were observed in FinnTwin12 (p ≤ .11). The discussion focuses on how the strength of intergenerational pathways for externalizing psychopathology may differ as a function of adolescent-level individual differences.

Indexed as

Life Change EventsPolymorphism, Single NucleotideAdolescentAggressionAlcoholismAllelesAntisocial Personality DisorderChildFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenotypeHumansMaleParent-Child RelationsParentsGABRA2 protein, humanReceptors, GABA-A

Identifiers

PMID26075969
PMCPMC4573794

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.