ArticlePloS one2015
Genetic Variation in NFKB1 and NFKBIA and Susceptibility to Coronary Artery Disease in a Chinese Uygur Population.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Significant association between rs28362491 polymorphism in NF-κB1 gene and coronary artery disease: a meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- Article
- A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.American journal of human genetics · 2024Article
- Giant Coronary Aneurysms with Multiple Large Resistant Thromboses in an 8-Month-Old Boy with IVIg-Resistant Kawasaki Disease: A Case Report.The journal of Tehran Heart Center · 2023Article
- Development and External Validation of Nomogram to Identify Risk Factors for CHD in T2DM in the Population of Northwestern China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Association of NFKB1 gene polymorphism (rs28362491) with cardiometabolic risk factor in patients undergoing coronary angiography.Journal of cardiovascular and thoracic research · 2023Article
- Elevated circulating inflammatory biomarker levels in the SIRT1-NF-κB-sCD40L pathway in patients with acute myocardial infarction: a case-control study.Annals of medicine · 2023Article
- Association of NFKB1 gene rs28362491 mutation with the occurrence of major adverse cardiovascular events.BMC cardiovascular disorders · 2022Article
- Article
- Influence of Polymorphism on theJournal of personalized medicine · 2021Article
- NFKB1 promoter -94 insertion/deletion ATTG polymorphism (rs28362491) is associated with severity and disease progression of rheumatoid arthritis through interleukin-6 levels modulation in Egyptian patients.Clinical rheumatology · 2021Article
- Association ofBalkan journal of medical genetics : BJMG · 2021Article
- Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification.Frontiers in immunology · 2021Review
- NFKB1 gene rs28362491 ins/del variation is associated with higher susceptibility to myocardial infarction in a Chinese Han population.Scientific reports · 2020Article
- Nuclear factor NF-κB1 functional promoter polymorphism and its expression conferring the risk of Type 2 diabetes-associated dyslipidemia.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Bioinformatics analysis of the regulatory lncRNA‑miRNA‑mRNA network and drug prediction in patients with hypertrophic cardiomyopathy.Molecular medicine reports · 2019Article
- NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome.Bioscience reports · 2019Article
- The association betweenMolecular biology research communications · 2018Article
- Association between serum osteocalcin and glucose/lipid metabolism in Chinese Han and Uygur populations with type 2 diabetes mellitus in Xinjiang: two cross-sectional studies.Lipids in health and disease · 2017Article
- Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease.Human genomics · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCoronary artery disease (CAD) is the most common chronic inflammatory disease worldwide. NF-κB, a central regulator of inflammation, is involved in various inflammatory diseases. The aim of this study was to investigate the association between NFKB1 and NFKBIA polymorphisms and the susceptibility to CAD and their impact on plasma levels of IL-6 in a Chinese Uygur population.
methodsWe genotyped NFKB1-94ins/del ATTG (rs28362491) and NFKBIA3' UTR A/G (rs696) using TaqMan SNP genotyping assays in 960 Uygur CAD cases and Uygur 1060 CAD-negative controls. IL-6 plasma levels were measured in 360 stable angina pectoris (SAP) cases and 360 controls using ELISA method.
resultsThere was no significant difference in the distribution of the genotypes and alleles of rs696 polymorphism in CAD cases and controls. Significant difference in the frequency of genotypes (P = 0.001) and alleles (P = 0.001) of rs28362491 polymorphism was observed in CAD cases compared to controls. In multivariate logistic regression analysis, SNP rs28362491 was consistently associated with CAD risk in a recessive model after adjustment for cardiovascular risk factors (OR = 1.581, 95% CI 1.222 to 2.046, P<0.001). SAP cases had significantly higher plasma levels of IL-6 compared to controls (P<0.001). General linear model analysis showed rs28362491 was independently associated with increased IL-6 levels by analyses of a recessive model (P<0.001) after adjustment for covariates.
conclusionsOur study indicates that NFKB1-94 ins/del ATTG polymorphism may play a role in CAD susceptibility in Chinese Uygur population and is functionally associated with IL-6 expression, suggesting a mechanistic link between NFKB1-94 ins/del ATTG polymorphism and CAD susceptibility.
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