ArticlePloS one2015
Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Disrupted circadian rhythms and opioid-mediated adverse effects: Bidirectional relationship and putative mechanisms.Journal of neuroendocrinology · 2025Review
- Differential Expression of Circadian Clock Genes in the Bovine Neuroendocrine Adrenal System.Genes · 2023Article
- An Intact Krüppel-like factor 9 Gene Is Required for Acute Liver Period 1 mRNA Response to Restraint Stress.Endocrinology · 2021Article
- The role of clock genes in sleep, stress and memory.Biochemical pharmacology · 2021Review
- Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.Neurobiology of disease · 2021Article
- Maternal Distress and Offspring Neurodevelopment: Challenges and Opportunities for Pre-clinical Research Models.Frontiers in human neuroscience · 2021Article
- Mood-related central and peripheral clocks.The European journal of neuroscience · 2020Review
- Circadian regulation of depression: A role for serotonin.Frontiers in neuroendocrinology · 2019Review
- GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2019Article
- Article
- Biological Clocks and Rhythms of Anger and Aggression.Frontiers in behavioral neuroscience · 2018Review
- Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues.The journal of physiological sciences : JPS · 2017Article
- Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms.Biological psychiatry · 2017Article
- The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids.Endocrine reviews · 2017Review
- Diurnal Variation of the Peripheral Cholinergic Antiinflammatory Function in Mice.CNS neuroscience & therapeutics · 2016Article
- Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease.F1000Research · 2016Review
- Performing a hepatic timing signal: glucocorticoids induce gper1a and gper1b expression and repress gclock1a and gbmal1a in the liver of goldfish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Implications of circadian rhythm and stress in addiction vulnerability.F1000Research · 2016Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secretion of glucocorticoids in mammals is under circadian control, but glucocorticoids themselves are also implicated in modulating circadian clock gene expression. We have shown that the expression of the circadian clock protein PER1 in the forebrain is modulated by stress, and that this effect is associated with changes in plasma corticosterone levels, suggesting a possible role for glucocorticoids in the mediation of stress-induced changes in the expression of PER1 in the brain. To study this, we assessed the effects of adrenalectomy and of pretreatment with the glucocorticoid receptor antagonist, mifepristone, on the expression of PER1 in select limbic and hypothalamic regions following acute exposure to a neurogenic stressor, restraint, or a systemic stressor, 2-Deoxy-D-glucose (2DG) in rats. Acute restraint suppressed PER1 expression in the oval nucleus of the bed nucleus of the stria terminalis (BNSTov) and the central nucleus of the amygdala (CEAl), whereas 2DG increased PER1 in both regions. Both stressors increased PER1 expression in the paraventricular (PVN) and dorsomedial (DMH) nuclei of the hypothalamus, and the piriform cortex (Pi). Adrenalectomy and pretreatment with mifepristone reversed the effects of both stressors on PER1 expression in the BNSTov and CEAl, and blocked their effects in the DMH. In contrast, both treatments enhanced the effects of restraint and 2DG on PER1 levels in the PVN. Stress-induced PER1 expression in the Pi was unaffected by either treatment. PER1 expression in the suprachiasmatic nucleus, the master circadian clock, was not altered by either exposure to stress or by the glucocorticoid manipulations. Together, the results demonstrate a key role for glucocorticoid signaling in stress-induced changes in PER1 expression in the brain.
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