ReviewThe aging male : the official journal of the International Society for the Study of the Aging Male2015
Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function.
Review in The aging male : the official journal of the International Society for the Study of the Aging Male, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Sex hormones and the risk of cardiovascular disease and mortality in male and female patients with chronic kidney disease: A systematic review and meta-analysis.Physiological reports · 2022Pooled it
- Sleep restriction and testosterone concentrations in young healthy males: randomized controlled studies of acute and chronic short sleep.Sleep health · 2019Trial
- Genetic ablation of the adult Leydig cell lineage reveals stem Leydig cells and a peritubular regenerative niche in mice.Endocrinology · 2026Article
- Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives.International journal of molecular sciences · 2026Review
- Review
- Dihydrotestosterone Pretreatment Diminishes the Severity of Drug-Induced Torsades de Pointes.Journal of cardiovascular pharmacology · 2025Article
- Lifestyle in flux: urbanization, dietary shifts, and endocrine health in emerging adulthood.Reproductive biology and endocrinology : RB&E · 2025Article
- Sex differences in the mediating role of brain-derived neurotrophic factor between inflammation and memory in cirrhotic patients with minimal hepatic encephalopathy.Brain, behavior, & immunity - health · 2025Article
- Review
- The relationship between follicle-stimulating hormone and metabolic dysfunction-associated fatty liver disease in men.Nutrition & diabetes · 2024Article
- Reproductive Ageing: Current insights and a potential role of NAD in the reproductive health of aging fathers and their children.Reproduction (Cambridge, England) · 2024Review
- Review
- Testosterone Replacement Therapy and Cardiovascular Disease: Balancing Safety and Risks in Hypogonadal Men.Current cardiology reports · 2023Review
- Elevated periprostatic venous testosterone correlates with prostate cancer progression after radical prostatectomy.The Journal of clinical investigation · 2023Article
- Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men.Metabolism open · 2023Article
- Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study.European journal of endocrinology · 2022Article
- Could Lower Testosterone in Older Men Explain Higher COVID-19 Morbidity and Mortalities?International journal of molecular sciences · 2022Review
- Effect of Li-ESWT on Testicular Tissue and Function in Androgen-Deficient Rat Model.Oxidative medicine and cellular longevity · 2022Article
- Reproductive Effects of Nicotinamide on Testicular Function and Structure in Old Male Rats: Oxidative, Apoptotic, Hormonal, and Morphological Analyses.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease.Antioxidants (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.