ArticleNature chemical biology2015
Control of carotenoid biosynthesis through a heme-based cis-trans isomerase.
Article in Nature chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 81 citations in OpenAlex.
- Comparative analysis of ZISO-mediated carotenoid biosynthesis in Dunaliella salina and Dunaliella bardawil.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Integrative Analysis of Metabolome and Transcriptome of Carotenoid Biosynthesis Reveals the Mechanism of Fruit Color Change in Tomato (International journal of molecular sciences · 2024Article
- Comparative transcriptomic and plastid development analysis sheds light on the differential carotenoid accumulation in kiwifruit flesh.Frontiers in plant science · 2023Article
- Leaf transcriptome analysis of Medicago ruthenica revealed its response and adaptive strategy to drought and drought recovery.BMC plant biology · 2022Article
- Zeta-Carotene Isomerase (Z-ISO) Is Required for Light-Independent Carotenoid Biosynthesis in the CyanobacteriumMicroorganisms · 2022Article
- Charge Maintenance during Catalysis in Nonheme Iron Oxygenases.ACS catalysis · 2022Article
- ClZISO mutation leads to photosensitive flesh in watermelon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Review
- Redox and Hormonal Changes in the Transcriptome of Grape (Plants (Basel, Switzerland) · 2022Article
- A foliar pigment-based bioassay for interrogating chloroplast signalling revealed that carotenoid isomerisation regulates chlorophyll abundance.Plant methods · 2022Article
- Alternative transcription and feedback regulation suggest that SlIDI1 is involved in tomato carotenoid synthesis in a complex way.Horticulture research · 2022Article
- Overexpression ofFrontiers in plant science · 2022Article
- Carotenoid metabolism: New insights and synthetic approaches.Frontiers in plant science · 2022Review
- Metalloenzymes involved in carotenoid biosynthesis in plants.Methods in enzymology · 2022Article
- Characterization of 15-Plants (Basel, Switzerland) · 2021Article
- A new regime of heme-dependent aromatic oxygenase superfamily.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A novel catalytic heme cofactor in SfmD with a single thioether bond and aChemical science · 2021Article
- ABSCISIC ACID-DEFICIENT4 Has an Essential Function in Both cis-Violaxanthin and cis-Neoxanthin Synthesis.Plant physiology · 2020Article
- Manipulation of ZDS in tomato exposes carotenoid- and ABA-specific effects on fruit development and ripening.Plant biotechnology journal · 2020Article
- Carotenoids modulate kernel texture in maize by influencing amyloplast envelope integrity.Nature communications · 2020Article
- Nonspecific Heme-Binding Cyclase, AbmU, Catalyzes [4 + 2] Cycloaddition during Neoabyssomicin Biosynthesis.ACS omega · 2020Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Plants synthesize carotenoids, which are essential for plant development and survival. These metabolites also serve as essential nutrients for human health. The biosynthetic pathway for all plant carotenoids occurs in chloroplasts and other plastids and requires 15-cis-ζ-carotene isomerase (Z-ISO). It was not known whether Z-ISO catalyzes isomerization alone or in combination with other enzymes. Here we show that Z-ISO is a bona fide enzyme and integral membrane protein. Z-ISO independently catalyzes the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-cis-ζ-carotene to produce the substrate required by the subsequent biosynthetic-pathway enzyme. We discovered that isomerization depends upon a ferrous heme b cofactor that undergoes redox-regulated ligand switching between the heme iron and alternate Z-ISO amino acid residues. Heme b-dependent isomerization of a large hydrophobic compound in a membrane was previously undescribed. As an isomerase, Z-ISO represents a new prototype for heme b proteins and potentially uses a new chemical mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.