ArticleFrontiers in cellular and infection microbiology2015
Identification of sdiA-regulated genes in a mouse commensal strain of Enterobacter cloacae.
Article in Frontiers in cellular and infection microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- The Quorum-Sensing Regulator SdiA ActivatesMicroorganisms · 2026Article
- Quorum sensing disruption in Enterobacter spp.: unlocking new therapeutic pathways against multidrug-resistant infections.Antonie van Leeuwenhoek · 2026Review
- The Type VI Secretion System of Sinorhizobium fredii USDA257 Is Required for Successful Nodulation With Glycine max cv Pekin.Microbial biotechnology · 2025Article
- Role of the LuxR solo, SdiA, in eavesdropping on foreign bacteria.FEMS microbiology reviews · 2025Review
- AHL-based QS signalling promotes uropathogenic Escherichia coli settlement through the de-repression of biofilm formation by SdiA.PloS one · 2025Article
- Polarity effects, resistance, and probiotic enhancement of intoxication of Salmonella enterica fraB mutants in murine models.PloS one · 2025Article
- Regulatory effects on virulence and phage susceptibility revealed byFrontiers in cellular and infection microbiology · 2025Article
- Regulatory Mechanisms and Physiological Impacts of Quorum Sensing in Gram-Negative Bacteria.Infection and drug resistance · 2024Review
- Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level.Microbiology (Reading, England) · 2023Review
- SdiA Enhanced the Drug Resistance ofFrontiers in microbiology · 2022Article
- SdiA, a Quorum-Sensing Regulator, Suppresses Fimbriae Expression, Biofilm Formation, and Quorum-Sensing Signaling Molecules Production inFrontiers in microbiology · 2021Article
- LuxR Solos in the Plant EndophyteApplied and environmental microbiology · 2020Article
- Anti-quorum sensing effects of licochalcone A and epigallocatechin-3-gallate againstVeterinary research forum : an international quarterly journal · 2020Article
- SdiA Improves the Acid Tolerance ofFrontiers in microbiology · 2020Article
- Molecular processes underlying synergistic linuron mineralization in a triple-species bacterial consortium biofilm revealed by differential transcriptomics.MicrobiologyOpen · 2018Article
- Quorum Sensing N-acyl Homoserine Lactones-SdiA SuppressesFrontiers in cellular and infection microbiology · 2017Article
- The Type VI Secretion System in Escherichia coli and Related Species.EcoSal Plus · 2016Review
- Editorial: LuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria.Frontiers in cellular and infection microbiology · 2015Article
- Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Many bacteria determine their population density using quorum sensing. The most intensively studied mechanism of quorum sensing utilizes proteins of the LuxI family to synthesize a signaling molecule of the acylhomoserine lactone (AHL) type, and a protein of the LuxR family to bind AHL and regulate transcription. Genes regulated by quorum sensing often encode functions that are most effective when a group of bacteria are working cooperatively (e.g., luminescence, biofilm formation, host interactions). Bacteria in the Escherichia, Salmonella, Klebsiella, and Enterobacter genera do not encode an AHL synthase but they do encode an AHL receptor of the LuxR family, SdiA. Instead of detecting their own AHL synthesis, these organisms use SdiA to detect the AHLs synthesized by other bacterial species. In this study, we used a genetic screen to identify AHL-responsive genes in a commensal Enterobacter cloacae strain that was isolated from a laboratory mouse. The genes include a putative type VI secretion system, copA (a copper transporter), and fepE (extends O-antigen chain length). A new transposon mutagenesis strategy and suicide vectors were used to construct an sdiA mutant of E. cloacae. The AHL-responsiveness of all fusions was entirely sdiA-dependent, although some genes were regulated by sdiA in the absence of AHL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.