Evidence map›Paper›PMID 26075186›Full record

ArticleFrontiers in cellular and infection microbiology2015

Differential induction of total IgE by two Salmonella enterica serotypes.

Zhanna A Ktsoyan, Mkhitar S Mkrtchyan, Magdalina K Zakharyan, Armine A Mnatsakanyan, Karine A Arakelova, Zaruhi U Gevorgyan, Lusntag A Ktsoyan, Anahit Ì Sedrakyan, Alvard I Hovhannisyan, Karine A Ghazaryan and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Potential Involvement ofPathogens (Basel, Switzerland) · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Zhanna A KtsoyanInstitute of Molecular Biology of National Academy of Sciences of Republic of Armenia Yerevan, Armenia.
Mkhitar S MkrtchyanInstitute of Molecular Biology of National Academy of Sciences of Republic of Armenia Yerevan, Armenia.
Magdalina K ZakharyanInstitute of Molecular Biology of National Academy of Sciences of Republic of Armenia Yerevan, Armenia.
Armine A Mnatsakanyan"Nork" Clinical Hospital of Infectious Diseases, Ministry of Health of the Republic of Armenia Yerevan, Armenia.
Karine A ArakelovaInstitute of Molecular Biology of National Academy of Sciences of Republic of Armenia Yerevan, Armenia.
Zaruhi U Gevorgyan"Nork" Clinical Hospital of Infectious Diseases, Ministry of Health of the Republic of Armenia Yerevan, Armenia.
Lusntag A KtsoyanYerevan State Medical University after Mkthitar Heratsi Yerevan, Armenia.
Anahit Ì SedrakyanInstitute of Molecular Biology of National Academy of Sciences of Republic of Armenia Yerevan, Armenia.
Alvard I HovhannisyanInstitute of Molecular Biology of National Academy of Sciences of Republic of Armenia Yerevan, Armenia.
Karine A GhazaryanInstitute of Molecular Biology of National Academy of Sciences of Republic of Armenia Yerevan, Armenia.
Anna S BoyajyanInstitute of Molecular Biology of National Academy of Sciences of Republic of Armenia Yerevan, Armenia.
Rustam I AminovNational Veterinary Institute, Technical University of Denmark Frederiksberg, Denmark.
Technical University of Denmark · DKYerevan State Medical University · AM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main goal of this study was to establish how the inflammation caused by infection with two different Salmonella enterica serotypes, S. Typhimurium and S. Enteritidis, may lead to the predisposition to allergy as measured by total IgE level in the blood. Infection by S. Typhimurium did not affect the systemic IgE concentration while in S. Enteritidis-infected patients there was a significant 3.5-fold increase. This effect was especially profound in patients >4 years old, with up to the 8-fold increase above the norm. The degree of dysbiosis in these two infections measured with the comparative counts of cultivated bacteria showed an inverse relationship with the IgE concentration. Earlier we reported the elevated level of IL-17 in patients infected by S. Enteritidis. In the current study a significant correlation was found between the concentrations of IL-17 and IgE suggesting a possible role played by this cytokine in triggering the production of IgE in response to S. Enteritidis infection.

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, BacterialChildChild, PreschoolCohort StudiesHumansImmunoglobulin EInfantInterleukin-17Middle AgedSalmonella enteritidisSalmonella typhimuriumYoung AdultAntibodies, BacterialImmunoglobulin EInterleukin-17IgEIL-17Salmonellasalmonellosisserotype

Identifiers

PMID26075186
PMCPMC4443841
OpenAlexW1563199834

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.