ArticleFrontiers in oncology2015
Trends and Characteristics of Young Non-Small Cell Lung Cancer Patients in the United States.
Article in Frontiers in oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses.BMJ open · 2025Pooled it
- Inherited genetic risk factors in young-onset lung cancer.medRxiv : the preprint server for health sciences · 2026Article
- Geospatial analysis as a tool for identification of potential targetable regions for lung cancer screening interventions in Massachusetts.Journal of thoracic disease · 2025Article
- Statewide Medicaid Expansion and Survival in Resectable Non-Small Cell Lung Cancer.JAMA network open · 2025Article
- Patient and Physician Preferences for Maintenance Treatment in Advanced Non-Small Cell Lung Cancer: Insights into Treatment Selection.Advances in therapy · 2025Article
- Survival Determinants and Sociodemographic Disparities in Early-Onset Non-Small Cell Lung Cancer.JAMA network open · 2025Article
- Article
- Lung cancer in young individuals; risk factors and epidemiology.Journal of thoracic disease · 2025Review
- A profile of lung cancer in the young population with a highlight on the Indian perspective.Frontiers in oncology · 2025Review
- Young lung cancer: from diagnosis to survivorship.Frontiers in oncology · 2025Review
- Article
- Development of Lung Cancer Risk Prediction Machine Learning Models for Equitable Learning Health System: Retrospective Study.JMIR AI · 2024Article
- A Nomogram for Predicting Cancer-Specific Survival in Young Patients With Advanced Lung Cancer Based on Competing Risk Model.The clinical respiratory journal · 2024Article
- Article
- Prospective validation of tumor folate receptor expression density with the association of pafolacianine fluorescence during intraoperative molecular imaging-guided lung cancer resections.European journal of nuclear medicine and molecular imaging · 2023Article
- Age-dependent genomic characteristics and their impact on immunotherapy in lung adenocarcinoma.Journal of cancer research and clinical oncology · 2023Article
- Personal and clinical characteristics associated with immunotherapy effectiveness in stage IV non-small cell lung cancer.Translational lung cancer research · 2023Article
- Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer.Open medicine (Warsaw, Poland) · 2023Article
- AI/ML advances in non-small cell lung cancer biomarker discovery.Frontiers in oncology · 2023Review
- Risk factors for early-onset lung cancer in Korea: analysis of a nationally representative population-based cohort.Epidemiology and health · 2023Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the median age at diagnosis of non-small cell lung cancer (NSCLC) is 70 years, a subset of patients with NSCLC present at a younger age (<40 years). Little is known about the time-trends in incidence of NSCLC in the young, their characteristics and outcomes.
methodsThe surveillance, epidemiology, and end results database was used to extract NSCLC cases from 1978 to 2010. Yearly incidence rates in various age groups, race, site of disease, histology, treatment patterns, and outcomes were assessed. We modeled Kaplan-Meyer survival curves stratified by age of presentation.
resultsYoung patients represented 0.6% of incident NSCLC from 1978 to 2010. The incidence of young NSCLC declined significantly during this time-period. Young NSCLCs had a higher proportion of women (51%), Asians or Pacific Islanders (14%), adenocarcinoma histology (59%) and were more likely to present with distant metastases (68%). The young had better all cause and lung cancer-specific survival than the older patients (median survival for localized, regional, and distant disease: not reached, 28, 9 vs. 46, 17, 5 months; p < 0.001 for all groups). Male sex, non-adenocarcinoma histology, and main bronchial primary were independent negative prognostic factors among the young. In contrast to the overall population, black race was a poor prognostic factor among the young.
conclusionThe incidence of NSCLC in the young decreased from 1978 to 2010. The clinical characteristics of NSCLC in the young, including demographic distribution, treatment, and outcomes are different from those observed in the older patients.
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