Evidence map›Paper›PMID 26075100›Full record

SynthesisNeural plasticity2015

Magnetic Seizure Therapy for Unipolar and Bipolar Depression: A Systematic Review.

Eric Cretaz, André R Brunoni, Beny Lafer

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neural plasticity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Magnetic seizure therapy for people with schizophrenia.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Pooled it
  3. Magnetic seizure therapy for treatment-resistant depression.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Guideline
  5. Pooled it
  6. Trial
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Magnetic seizure therapy.Industrial psychiatry journal · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Precision non-implantable neuromodulation therapies: a perspective for the depressed brain.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Eric CretazService of Electroconvulsive Therapy, Department and Institute of Psychiatry, University of São Paulo, Dr. Ovídio Pires de Campos Street 785, 05403-903 São Paulo, SP, Brazil ; Bipolar Disorder Research Program, Department and Institute of Psychiatry, University of São Paulo, Dr. Ovídio Pires de Campos Street 785, 05403-903 São Paulo, SP, Brazil.
André R BrunoniService of Interdisciplinary Neuromodulation (SIN), Laboratory of Neurosciences (LIM-27), Department and Institute of Psychiatry, University of São Paulo, Dr. Ovídio Pires de Campos Street 785, 05403-903 São Paulo, SP, Brazil.
Beny LaferBipolar Disorder Research Program, Department and Institute of Psychiatry, University of São Paulo, Dr. Ovídio Pires de Campos Street 785, 05403-903 São Paulo, SP, Brazil.ORCID 0000-0002-6132-9999
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledObjective. Magnetic seizure therapy (MST) is a novel, experimental therapeutic intervention, which combines therapeutic aspects of electroconvulsive therapy (ECT) and transcranial magnetic stimulation, in order to achieve the efficacy of the former with the safety of the latter. MST might prove to be a valuable tool in the treatment of mood disorders, such as major depressive disorder (MDD) and bipolar disorder. Our aim is to review current literature on MST. Methods. OVID and MEDLINE databases were used to systematically search for clinical studies on MST. The terms "magnetic seizure therapy," "depression," and "bipolar" were employed. Results. Out of 74 studies, 8 met eligibility criteria. There was considerable variability in the methods employed and samples sizes were small, limiting the generalization of the results. All studies focused on depressive episodes, but few included patients with bipolar disorder. The studies found reported significant antidepressant effects, with remission rates ranging from 30% to 40%. No significant cognitive side effects related to MST were found, with a better cognitive profile when compared to ECT.

conclusionMST was effective in reducing depressive symptoms in mood disorders, with generally less side effects than ECT. No study focused on comparing MST to ECT on bipolar depression specifically.

Indexed as

Bipolar DisorderBrainElectroconvulsive TherapyHumansMajor Depressive DisorderSeizuresTranscranial Magnetic StimulationTreatment Outcome

Identifiers

PMID26075100
PMCPMC4444586
OpenAlexW1545669712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.