ReviewNursing research and practice2015
Disinfection of Needleless Connector Hubs: Clinical Evidence Systematic Review.
Review in Nursing research and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03605498 (An Investigation of Novel Technology to Bring Genomic Analysis to the Patient Bedside to Systematically Track and Report on ESKAPE Bacterial Transmission in Today's Operating Room Environments), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Investigation of Novel Technology to Bring Genomic Analysis to the Patient Bedside to Systematically Track and Report on ESKAPE Bacterial Transmission in Today's Operating Room Environments
Who cites it
27 citing papers in PubMed, 107 citations in OpenAlex.
- Prevention of arterial catheter-related bloodstream infections: current evidence and future directions.Critical care (London, England) · 2026Review
- Reducing Central Line-Associated Bloodstream Infections in the ICU: A Nurse-Led Evidence Based Quality Improvement Initiative.Nursing open · 2026Article
- Practice guideline on the prevention and treatment of central line-associated bloodstream infection: Part 2 - Treatment.Journal of intensive medicine · 2026Article
- The Safety and Efficacy of Disinfection Cap Use in a Real-World Environment.Medical devices (Auckland, N.Z.) · 2026Article
- Temporal and anatomic determinants of central-line-associated bloodstream infection risk in a tertiary PICU: a 3-year time-to-event and competing-risk analysis.Frontiers in pediatrics · 2026Article
- Enhancing Safety in Clinical Practice: Cross-Sectional, Within-Subjects, Simulated-Use Compliance Study Using BD PosiFlush SafeScrub.JMIR human factors · 2025Article
- Dual Action Nitric Oxide-Releasing Polydimethylsiloxane Sponge: Preventing Infection in Needleless Connectors.ACS applied bio materials · 2025Article
- Appropriateness of intravenous fluid prescriptions in hospitalised patients: a point prevalence study.International journal of clinical pharmacy · 2025Article
- Prevention of Catheter-Related Infections and Complications: A Narrative Literature Review of Vascular Care and Maintenance.International journal of vascular medicine · 2025Review
- Practical Guidance for Clinical Microbiology Laboratories: Microbiologic diagnosis of implant-associated infections.Clinical microbiology reviews · 2024Review
- Efficacy of disinfection procedures to reduceInfection prevention in practice · 2024Article
- Integration of Riboflavin-Modified Carbon Fiber Mesh Electrode Systems in a 3D-Printed Catheter Hub.Micromachines · 2023Article
- A mixed-methods evaluation on the efficacy and perceptions of needleless connector disinfectants.Infection control and hospital epidemiology · 2023Article
- Environmental, Microbiological, and Immunological Features of Bacterial Biofilms Associated with Implanted Medical Devices.Clinical microbiology reviews · 2022Review
- Working on the dirty side-the ipsilateral subclavian access for temporary pacing after lead extraction.Journal of arrhythmia · 2022Article
- Adherence to central venous catheter maintenance bundle in an intensive care unit.Revista da Escola de Enfermagem da U S P · 2022Article
- Microbiological colonization of peripheral venous catheters: a prospective observational study in a Swedish county hospital.Infection prevention in practice · 2021Article
- Preclinical evaluation of passive disinfection caps with a long-term catheter for the prevention of catheter-related bloodstream infection in pediatric cancer patients.GMS hygiene and infection control · 2021Article
- Minimising Blood Stream Infection: Developing New Materials for Intravascular Catheters.Medicines (Basel, Switzerland) · 2020Review
- Cannula and circuit management in peripheral extracorporeal membrane oxygenation: An international survey of 45 countries.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Needleless connectors (NC) are used on virtually all intravascular devices, providing an easy access point for infusion connection. Colonization of NC is considered the cause of 50% of postinsertion catheter-related infections. Breaks in aseptic technique, from failure to disinfect, result in contamination and subsequent biofilm formation within NC and catheters increasing the potential for infection of central and peripheral catheters. Methods. This systematic review evaluated 140 studies and 34 abstracts on NC disinfection practices, the impact of hub contamination on infection, and measures of education and compliance. Results. The greatest risk for contamination of the catheter after insertion is the NC with 33-45% contaminated, and compliance with disinfection as low as 10%. The optimal technique or disinfection time has not been identified, although scrubbing with 70% alcohol for 5-60 seconds is recommended. Studies have reported statistically significant results in infection reduction when passive alcohol disinfection caps are used (48-86% reduction). Clinical Implications. It is critical for healthcare facilities and clinicians to take responsibility for compliance with basic principles of asepsis compliance, to involve frontline staff in strategies, to facilitate education that promotes understanding of the consequences of failure, and to comply with the standard of care for hub disinfection.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.