Evidence map›Paper›PMID 26074985›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2015

Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats.

Roger Yazbeck, Ruth Lindsay, Catherine A Abbott, Kirsten Benkendorff, Gordon S Howarth

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Roger YazbeckSansom Institute, University of South Australia, Adelaide, SA 5000, Australia ; Basil Hetzel Institute, Queen Elizabeth Hospital, Woodville, SA 5011, Australia ; Gastroenterology Department, Women's and Children's Hospital, Adelaide, SA 5000, Australia ; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Adelaide, SA 5371, Australia ; School of Biological Sciences, Flinders University, Adelaide, SA 5000, Australia.
Ruth LindsayGastroenterology Department, Women's and Children's Hospital, Adelaide, SA 5000, Australia ; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Adelaide, SA 5371, Australia.
Catherine A AbbottSchool of Biological Sciences, Flinders University, Adelaide, SA 5000, Australia ; Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, SA 5000, Australia.
Kirsten BenkendorffSchool of Biological Sciences, Flinders University, Adelaide, SA 5000, Australia ; Marine Ecology Research Center, School of Environment, Science and Engineering, Southern Cross University, Lismore, NSW 2480, Australia.
Gordon S HowarthBasil Hetzel Institute, Queen Elizabeth Hospital, Woodville, SA 5011, Australia ; Gastroenterology Department, Women's and Children's Hospital, Adelaide, SA 5000, Australia ; School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Adelaide, SA 5371, Australia.
Flinders University · AUWomen's and Children's Hospital · AUSouthern Cross University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy drugs, such as 5-fluorouracil (5FU), are the standard approach for cancer and are associated with several peripheral toxicities. We previously demonstrated that Muricidae marine molluscs exhibit chemopreventive properties. This study investigated the combined effect of muricid extract derived from Dicathais orbita, with 5FU, on intestinal toxicity in rats. Groups of rats were orally gavaged water, muricid extract, or sunflower oil, with or without 5FU (150 mg/kg). Metabolic data was collected daily and small intestinal brush border enzyme activity was measured by sucrose breath test (SBT). Blood was collected by cardiac puncture for whole blood analysis. Intestinal biopsies were taken for histopathology. Neutrophil activity was measured by myeloperoxidase activity. No additional toxicity effects were observed in rats receiving the combination of 5FU and muricid extract compared to 5FU alone, as indicated by SBT, histopathology, and myeloperoxidase activity. Intestinal integrity was protected from 5FU-induced damage in the sunflower oil vehicle group, compared to controls, as measured by SBT, villus height, and crypt depth. We concluded that combination of muricid extract and 5FU did not confer any additional intestinal toxicity, further supporting its potential as a chemopreventive food product. In this model system, sunflower oil partially protected against 5FU-induced intestinal toxicity.

Identifiers

PMID26074985
PMCPMC4444572
OpenAlexW1546508046

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.