Evidence map›Paper›PMID 26074976›Full record

ArticleStem cells international2015

Exosomes Secreted from CXCR4 Overexpressing Mesenchymal Stem Cells Promote Cardioprotection via Akt Signaling Pathway following Myocardial Infarction.

Kai Kang, Ruilian Ma, Wenfeng Cai, Wei Huang, Christian Paul, Jialiang Liang, Yuhua Wang, Tiejun Zhao, Ha Won Kim, Meifeng Xu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 2 syntheses or guidelines pooled it, 213 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. The Potential of Mesenchymal Stem Cell-Derived Exosomes in Cardiac Repair.International journal of molecular sciences · 2024
    Review
  20. Article

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Kai KangDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Ruilian MaDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA ; Department of Cardiology, The People's Hospital of Sanya, Sanya, Hainan 572000, China.
Wenfeng CaiDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Wei HuangDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Christian PaulDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Jialiang LiangDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Yuhua WangDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Tiejun ZhaoDepartment of Urinary Surgery, Xining City Hospital, Qinghai 810000, China.
Ha Won KimDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Meifeng XuDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Ronald W MillardDepartment of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Zhili WenInfection Hospital of Nanchang University, Nanchang, Jiangxi 330002, China.
Yigang WangDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
University of Cincinnati Medical Center · USNanchang University · CNSanya Central Hospital · CNUniversity of Cincinnati · US

Funding

Angiomyogenesis With Myoblast Derived iPS CellsR01HL107957 · NHLBI · UNIVERSITY OF CINCINNATI · PI WANG, YIGANG · 2011 to 2015
$3.4M
iPS cells-derived progenitor cells for angiomyogenesisR01HL110740 · NHLBI · UNIVERSITY OF CINCINNATI · PI ASHRAF, MUHAMMAD, WANG, YIGANG · 2011 to 2015
$2.9M
MicroRNA as mediators of angiogenesis & ischemic myocardial repairR01HL114654 · NHLBI · UNIVERSITY OF CINCINNATI · PI ASHRAF, MUHAMMAD, XU, MEIFENG · 2012 to 2016
$2.5M
Stem Cell TherapyR01HL089824 · NHLBI · UNIVERSITY OF CINCINNATI · PI WANG, YIGANG · 2008 to 2012
$1.9M
Wnt11 signaling in stem cell survival and cardiac regenerationR01HL105176 · NHLBI · UNIVERSITY OF CINCINNATI · PI ASHRAF, MUHAMMAD, JONES, WALTER KEITH · 2010 to 2014
$1.9M
NHLBI NIH HHS R01 HL089824NHLBI NIH HHS R01 HL105176NHLBI NIH HHS R01 HL107957NHLBI NIH HHS R01 HL110740NHLBI NIH HHS R01 HL114654
6 · The paper itself

Abstract

Background and Objective. Exosomes secreted from mesenchymal stem cells (MSC) have demonstrated cardioprotective effects. This study examined the role of exosomes derived from MSC overexpressing CXCR4 for recovery of cardiac functions after myocardial infarction (MI). Methods. In vitro, exosomes from MSC transduced with lentiviral CXCR4 (Exo(CR4)) encoding a silencing sequence or null vector were isolated and characterized by transmission electron microscopy and dynamic light scattering. Gene expression was then analyzed by qPCR and Western blotting. Cytoprotective effects on cardiomyocytes were evaluated and effects of exosomes on angiogenesis analyzed. In vivo, an exosome-pretreated MSC-sheet was implanted into a region of scarred myocardium in a rat MI model. Angiogenesis, infarct size, and cardiac functions were then analyzed. Results. In vitro, Exo(CR4) significantly upregulated IGF-1α and pAkt levels and downregulated active caspase 3 level in cardiomyocytes. Exo(CR4) also enhanced VEGF expression and vessel formation. However, effects of Exo(CR4) were abolished by an Akt inhibitor or CXCR4 knockdown. In vivo, Exo(CR4) treated MSC-sheet implantation promoted cardiac functional restoration by increasing angiogenesis, reducing infarct size, and improving cardiac remodeling. Conclusions. This study reveals a novel role of exosomes derived from MSC(CR4) and highlights a new mechanism of intercellular mediation of stem cells for MI treatment.

Identifiers

PMID26074976
PMCPMC4436515
OpenAlexW1834712221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.