ArticleFrontiers in behavioral neuroscience2015
A Bayesian context fear learning algorithm/automaton.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Immune receptor LAG3 regulates microglia function during Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Learning, sleep replay and consolidation of contextual fear memories: A neural network model.PLoS computational biology · 2026Article
- A neurally constrained computational model of context-dependent fear extinction recall and relapse.Communications biology · 2025Article
- Hippocampal Engrams and Contextual Memory.Advances in neurobiology · 2024Review
- Editorial: Cortico-hippocampal interactions during learning and memory.Frontiers in behavioral neuroscience · 2024Article
- Partial or Complete Loss of Norepinephrine Differentially Alters Contextual Fear and Catecholamine Release Dynamics in Hippocampal CA1.Biological psychiatry global open science · 2024Article
- Control of contextual memory through interneuronal α5-GABAPNAS nexus · 2023Article
- Changes in Memory, Sedation, and Receptor Kinetics Imparted by the β2-N265M and β3-N265M GABAInternational journal of molecular sciences · 2023Article
- Remote memory in a Bayesian model of context fear conditioning (BaconREM).Frontiers in behavioral neuroscience · 2023Article
- Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP.Neuropharmacology · 2022Article
- Sex differences in contextual fear learning and generalization: a behavioral and computational analysis of hippocampal functioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Sexually dimorphic muscarinic acetylcholine receptor modulation of contextual fear learning in the dentate gyrus.Neurobiology of learning and memory · 2021Article
- Extinction and discrimination in a Bayesian model of context fear conditioning (BaconX).Hippocampus · 2021Article
- Engram Size Varies with Learning and Reflects Memory Content and Precision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The environmental sculpting hypothesis of juvenile and adult hippocampal neurogenesis.Progress in neurobiology · 2021Article
- Ventro-dorsal Hippocampal Pathway Gates Novelty-Induced Contextual Memory Formation.Current biology : CB · 2021Article
- Review
- Contextual processing elicits sex differences in dorsal hippocampus activation following footshock and context fear retrieval.Behavioural brain research · 2020Article
- Exposure Therapy for Post-Traumatic Stress Disorder: Factors of Limited Success and Possible Alternative Treatment.Brain sciences · 2020Article
- The Neurobiology of Fear Generalization.Frontiers in behavioral neuroscience · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Contextual fear conditioning is thought to involve the synaptic plasticity-dependent establishment in hippocampus of representations of to-be-conditioned contexts which can then become associated with USs in the amygdala. A conceptual and computational model of this process is proposed in which contextual attributes are assumed to be sampled serially and randomly during contextual exposures. Given this assumption, moment-to-moment information about such attributes will often be quite different from one exposure to another and, in particular, between exposures during which representations are created, exposures during which conditioning occurs, and during recall sessions. This presents challenges to current conceptual models of hippocampal function. In order to meet these challenges, our model's hippocampus was made to operate in different modes during representation creation and recall, and non-hippocampal machinery was constructed that controlled these hippocampal modes. This machinery uses a comparison between contextual information currently observed and information associated with existing hippocampal representations of familiar contexts to compute the Bayesian Weight of Evidence that the current context is (or is not) a known one, and it uses this value to assess the appropriateness of creation or recall modes. The model predicts a number of known phenomena such as the immediate shock deficit, spurious fear conditioning to contexts that are absent but similar to actually present ones, and modulation of conditioning by pre-familiarization with contexts. It also predicts a number of as yet unknown phenomena.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.