ArticleFrontiers in cellular neuroscience2015
Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: a novel translational research tool for psychiatric disorders.
Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- miR-214-3p and NCKAP1: A microglial functional dimension of Alzheimer's progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- IL-34 in neurological homeostasis and its multifaceted roles in central nervous system diseases.Frontiers in immunology · 2026Review
- Novel Cell Models to Study Myelin and Microglia Interactions.International journal of molecular sciences · 2025Article
- Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer's disease.Journal of neuroinflammation · 2024Article
- Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease.Scientific reports · 2023Article
- Role of NCKAP1 in the Defective Phagocytic Function of Microglia-Like Cells Derived from Rapidly Progressing Sporadic ALS.Molecular neurobiology · 2023Article
- Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice.Molecular brain · 2023Article
- Sex and the Estrous-Cycle Phase Influence the Expression of G Protein-Coupled Estrogen Receptor 1 (GPER) in Schizophrenia: Translational Evidence for a New Target.Molecular neurobiology · 2023Article
- A molecular characterization and clinical relevance of microglia-like cells derived from patients with panic disorder.Translational psychiatry · 2023Article
- Tools for studying human microglia: In vitro and in vivo strategies.Brain, behavior, and immunity · 2023Review
- Advancing basic and translational research to deepen understanding of the molecular immune-mediated mechanisms regulating long-term persistence of HIV-1 in microglia in the adult human brain.Journal of leukocyte biology · 2022Review
- The role of microglia in neuropsychiatric disorders and suicide.European archives of psychiatry and clinical neuroscience · 2022Review
- Recent Advances in Microglia Modelling to Address Translational Outcomes in Neurodegenerative Diseases.Cells · 2022Review
- Microglia Activation in Basal Ganglia Is a Late Event in Huntington Disease Pathophysiology.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Aged Microglia in Neurodegenerative Diseases: Microglia Lifespan and Culture Methods.Frontiers in aging neuroscience · 2021Review
- CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma.Frontiers in immunology · 2021Article
- Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies.Frontiers in cellular neuroscience · 2019Article
- A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.Science translational medicine · 2017Article
- Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke.International journal of molecular sciences · 2017Review
- Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microglia, glial cells with immunological functions, have been implicated in various neurological diseases and psychiatric disorders in rodent studies, and human postmortem and PET studies. However, the deeper molecular implications of living human microglia have not been clarified. Here, we introduce a novel translational research approach focusing on human microglia. We have recently developed a new technique for creating induced microglia-like (iMG) cells from human peripheral blood. Two cytokines, GM-CSF and IL-34, converted human monocytes into the iMG cells within 14 days, which show various microglial characterizations; expressing markers, forming a ramified morphology, and phagocytic activity with various cytokine releases. We have already confirmed the applicability of this technique by analyzing iMG cells from a patient of Nasu-Hakola disease (NHD; Ohgidani et al., 2014). We herein show possible applications of the iMG cells in translational research. We believe that this iMG technique will open the door to explore various unknown dynamic aspects of human microglia in psychiatric disorders. This also opens new routes for psychopharmacological approach such as drug efficacy screening and personalized medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.