ArticleFrontiers in molecular neuroscience2015
Suppression of NMDA receptor function in mice prenatally exposed to valproic acid improves social deficits and repetitive behaviors.
Article in Frontiers in molecular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- NMDA antagonist agents for the treatment of symptoms in autism spectrum disorder: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- A Systematic Review of the MDMA Model to Address Social Impairment in Autism.Current neuropharmacology · 2021Pooled it
- Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency.Science advances · 2026Article
- Prenatal Exposure to Lipopolysaccharide or Valproate Leads to Abnormal Accumulation of the NMDA Receptor Agonist D-Aspartate in the Adolescent Rat Brain.Journal of neurochemistry · 2025Article
- Disrupted functional connectome in a rodent model of autism during social isolation.Frontiers in neural circuits · 2025Article
- An alpha 5-GABAAutism research : official journal of the International Society for Autism Research · 2024Article
- Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice.Translational psychiatry · 2024Article
- N-Methyl-D-Aspartate (NMDA) Receptor Antagonists and their Pharmacological Implication: A Medicinal Chemistry-oriented Perspective Outline.Current medicinal chemistry · 2024Review
- The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions.Frontiers in neuroscience · 2024Review
- Alteration in social interaction and tactile discrimination of juvenile autistic-like rats following tactile stimulation and whisker deprivation.Brain and behavior · 2023Article
- Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Serotonin disruption at gestation alters expression of genes associated with serotonin synthesis and reuptake at weaning.Psychopharmacology · 2022Article
- Behavioral Deficits in Adolescent Mice after Sub-Chronic Administration of NMDA during Early Stage of Postnatal Development.Biomolecules & therapeutics · 2022Article
- Critical Evaluation of Valproic Acid-Induced Rodent Models of Autism: Current and Future Perspectives.Journal of molecular neuroscience : MN · 2022Review
- Novel probiotic treatment of autism spectrum disorder associated social behavioral symptoms in two rodent models.Scientific reports · 2022Article
- Sex differences in neuronal systems function and behaviour: beyond a single diagnosis in autism spectrum disorders.Translational psychiatry · 2021Review
- The Multi-Targeting Ligand ST-2223 with Histamine HInternational journal of molecular sciences · 2021Article
- Valproic acid-exposed astrocytes impair inhibitory synapse formation and function.Scientific reports · 2021Article
- A Need for Consistency in Behavioral Phenotyping for ASD: Analysis of the Valproic Acid Model.Autism research and treatment · 2021Review
- Altered Grooming Syntax and Amphetamine-Induced Dopamine Release in EAAT3 Overexpressing Mice.Frontiers in cellular neuroscience · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals prenatally exposed to valproic acid (VPA), an antiepileptic agent, have been used as a model for autism spectrum disorders (ASDs). Previous studies have identified enhanced NMDA receptor (NMDAR) function in the brain of VPA rats, and demonstrated that pharmacological suppression of NMDAR function normalizes social deficits in these animals. However, whether repetitive behavior, another key feature of ASDs, can be rescued by NMDAR inhibition remains unknown. We report here that memantine, an NMDAR antagonist, administered to VPA mice rescues both social deficits and repetitive behaviors such as self-grooming and jumping. These results suggest that suppression of elevated NMDAR function in VPA animals normalizes repetitive behaviors in addition to social deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.