ArticleFrontiers in neuroscience2015
Pineal melatonin is a circadian time-giver for leptin rhythm in Syrian hamsters.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Circadian profiles of free plasma metanephrines in anorexia nervosa and constitutional thinness.Endocrine · 2026Article
- Photoneuroendocrine, circadian and seasonal systems: from photoneuroendocrinology to circadian biology and medicine.Cell and tissue research · 2025Review
- Optimizing Chronotherapy in Psychiatric Care: The Impact of Circadian Rhythms on Medication Timing and Efficacy.Clocks & sleep · 2024Review
- Melatonin Alleviates the Impairment of Muscle Bioenergetics and Protein Quality Control Systems in Leptin-Deficiency-Induced Obesity.Antioxidants (Basel, Switzerland) · 2023Article
- Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism.International journal of molecular sciences · 2023Review
- Different levels of circadian (de)synchrony -- where does it hurt?F1000Research · 2022Review
- Aberrant Lighting Causes Anxiety-like Behavior in Mice but Curcumin Ameliorates the Symptoms.Animals : an open access journal from MDPI · 2021Article
- Physiological mechanisms underlying children's circannual growth patterns and their contributions to the obesity epidemic in elementary school age children.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Review
- Rumen-Protected 5-Hydroxytryptophan Improves Sheep Melatonin Synthesis in the Pineal Gland and Intestinal Tract.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism.Frontiers in endocrinology · 2019Review
- Light at night as an environmental endocrine disruptor.Physiology & behavior · 2018Review
- Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator.Frontiers in physiology · 2018Article
- Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude.Frontiers in physiology · 2018Article
- Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats.Frontiers in endocrinology · 2018Article
- Circadian and Metabolic Effects of Light: Implications in Weight Homeostasis and Health.Frontiers in neurology · 2017Review
- Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain Injury.Cellular and molecular neurobiology · 2016Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nocturnal secretion of melatonin from the pineal gland may affect central and peripheral timing, in addition to its well-known involvement in the control of seasonal physiology. The Syrian hamster is a photoperiodic species, which displays gonadal atrophy and increased adiposity when adapted to short (winter-like) photoperiods. Here we investigated whether pineal melatonin secreted at night can impact daily rhythmicity of metabolic hormones and glucose in that seasonal species. For that purpose, daily variations of plasma leptin, cortisol, insulin and glucose were analyzed in pinealectomized hamsters, as compared to sham-operated controls kept under very long (16 h light/08 h dark) or short photoperiods (08 h light/16 h dark). Daily rhythms of leptin under both long and short photoperiods were blunted by pinealectomy. Furthermore, the phase of cortisol rhythm under a short photoperiod was advanced by 5.6 h after pinealectomy. Neither plasma insulin, nor blood glucose displays robust daily rhythmicity, even in sham-operated hamsters. Pinealectomy, however, totally reversed the decreased levels of insulin under short days and the photoperiodic variations in mean levels of blood glucose (i.e., reduction and increase in long and short days, respectively). Together, these findings in Syrian hamsters show that circulating melatonin at night drives the daily rhythmicity of plasma leptin, participates in the phase control of cortisol rhythm and modulates glucose homeostasis according to photoperiod-dependent metabolic state.
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