Evidence map›Paper›PMID 26074744›Full record

ReviewCurrent neuropharmacology2015

Caffeine: cognitive and physical performance enhancer or psychoactive drug?

Simone Cappelletti, Daria Piacentino, Piacentino Daria, Gabriele Sani, Mariarosaria Aromatario

Erratum issued 2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neuropharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 226 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03720665 nacompletednot on this mapstarted 2018, after this paper: background citation

Cortical Excitability Changes on the Sensorimotor Cortex Induced by Caffeine Consumption: A TMS Study

TypeinterventionalSponsorUniversity Medical Center GoettingenRan2018 to 2019Enrolled30ConditionsCortical Excitability, Brain StimulationArmsCaffeine_TMS
NCT04011670 nacompletednot on this mapstarted 2019, after this paper: background citation

Neuroplastic Alterations of the Motor Cortex by Caffeine: Differences Between Caffeine and Non-caffeine Users and Influence of Vigilance During Stimulation

TypeinterventionalSponsorUniversity Medical Center GoettingenRan2019 to 2019Enrolled30ConditionsCortical Excitability, Brain Stimulation, CaffeineArms200 mg caffeine tablet, Non-active tablet
3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
    Daria, Piacentino [corrected to Piacentino, Daria]
5 · Who and what money

Authors and funding

5 authors.

Simone CappellettiDepartment of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, "Sapienza" University of Rome, Rome, Italy;
Daria Piacentino
Piacentino DariaNESMOS (Neuroscience, Mental Health, and Sensory Organs) Department, School of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
Gabriele SaniNESMOS (Neuroscience, Mental Health, and Sensory Organs) Department, School of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
Mariarosaria AromatarioDepartment of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, "Sapienza" University of Rome, Rome, Italy;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caffeine use is increasing worldwide. The underlying motivations are mainly concentration and memory enhancement and physical performance improvement. Coffee and caffeine-containing products affect the cardiovascular system, with their positive inotropic and chronotropic effects, and the central nervous system, with their locomotor activity stimulation and anxiogenic-like effects. Thus, it is of interest to examine whether these effects could be detrimental for health. Furthermore, caffeine abuse and dependence are becoming more and more common and can lead to caffeine intoxication, which puts individuals at risk for premature and unnatural death. The present review summarizes the main findings concerning caffeine's mechanisms of action (focusing on adenosine antagonism, intracellular calcium mobilization, and phosphodiesterases inhibition), use, abuse, dependence, intoxication, and lethal effects. It also suggests that the concepts of toxic and lethal doses are relative, since doses below the toxic and/or lethal range may play a causal role in intoxication or death. This could be due to caffeine's interaction with other substances or to the individuals' preexisting metabolism alterations or diseases.

Indexed as

Athletic PerformanceCaffeineCentral Nervous System StimulantsDrug UtilizationHumansNootropic AgentsSubstance-Related DisordersCaffeineCentral Nervous System StimulantsNootropic AgentsAbusecaffeinecoffeedependenceenergy drinkssafety dosestoxicity

Identifiers

PMID26074744
PMCPMC4462044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.