ArticleWorld journal of gastroenterology2015
Low G preconditioning reduces liver injury induced by high +Gz exposure in rats.
Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Alterations in the hepatic drug-metabolizing enzyme network of mice induced by +Gz exposure and its impact on the pharmacokinetics and pharmacodynamics of modafinil.Frontiers in pharmacology · 2026Article
- The effect of T cell aging on the change of human tissue structure.Immunity & ageing : I & A · 2024Article
- Protein succinylation, hepatic metabolism, and liver diseases.World journal of hepatology · 2024Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of repeated lower +Gz exposure on liver injury induced by high +Gz exposure in rats.
methodsSixty male Wister rats were randomly divided into a blank control group, a low G preconditioning group (LG) (exposed to +4 Gz/5 min per day for 3 d before +10 Gz/5 min exposure), and a +10 Gz/5 min group (10G) (n = 20 in each group). Blood specimens and liver tissue were harvested at 0 h and 6 h after +10 Gz/5 min exposure. Liver function was analyzed by measuring serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, and liver injury was further assessed by histopathological observation. Malondialdehyde (MDA), superoxide dismutase (SOD) and Na(+)-K(+)-ATPase were determined in hepatic tissue.
resultsThe group LG had lower ALT, AST, and MDA values at 0 h after exposure than those in group 10G. SOD values and Na(+)-K(+)-ATPase activity in the LG group were higher than in group 10G 0 h post-exposure. Hepatocyte injury was significantly less in group LG than in group 10G on histopathological evaluation.
conclusionIt is suggested that repeated low +Gz exposure shows a protective effect on liver injury induced by high +Gz exposure in rats.
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