ArticleDisease markers2015
The Expression of Notch/Notch Ligand, IL-35, IL-17, and Th17/Treg in Preeclampsia.
Article in Disease markers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Regulatory T Cells in Pregnancy Adverse Outcomes: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Unveiling the Diagnostic and Prognostic Value of Inflammatory Cytokines in Preeclampsia: A Review of Ιnterleukins IL-15, IL-16, IL-17 and IL-35.Journal of clinical medicine · 2025Review
- Understanding the role of immune-mediated inflammatory disease related cytokines interleukin 17 and 23 in pregnancy: A systematic review.Journal of translational autoimmunity · 2025Review
- A comprehensive review of the roles of T-cell immunity in preeclampsia.Frontiers in immunology · 2025Review
- Screening Preeclampsia Genes and the Effects of CITED2 on Trophoblastic Function.International journal of general medicine · 2024Article
- Immune Markers, Blood Pressure Severity, and Cardiac Remodeling 1 to 2 Years After Hypertensive Disorders of Pregnancy.Journal of the American Heart Association · 2023Article
- Plasma Olink Proteomics Identifies CCL20 as a Novel Predictive and Diagnostic Inflammatory Marker for Preeclampsia.Journal of proteome research · 2022Article
- Adipose-Derived Stem Cell Exosomes Inhibit Hypertrophic Scaring Formation by Regulating Th17/Treg Cell Balance.BioMed research international · 2022Article
- Cellular immune responses in the pathophysiology of preeclampsia.Journal of leukocyte biology · 2022Review
- Mechanism of Xiaoying Daotan decoction in treating Hashimoto's thyroiditis based on the Notch/Treg/Th17 pathway.Annals of translational medicine · 2021Article
- Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction.Frontiers in immunology · 2021Review
- Identifying key genes and drug screening for preeclampsia based on gene expression profiles.Oncology letters · 2020Article
- The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African Women.Infectious diseases in obstetrics and gynecology · 2020Article
- IL-35 interferes with splenic T cells in a clinical and experimental model of acute respiratory distress syndrome.International immunopharmacology · 2019Article
- Maternal lipids, BMI and IL-17/IL-35 imbalance in concurrent gestational diabetes mellitus and preeclampsia.Experimental and therapeutic medicine · 2018Article
- Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris.Mediators of inflammation · 2018Article
- Association between cytokine profile and transcription factors produced by T-cell subsets in early- and late-onset pre-eclampsia.Immunology · 2017Article
- A Dormant Microbial Component in the Development of Preeclampsia.Frontiers in medicine · 2016Review
- Evaluation of IL-17 and IL-35 Serum Levels in Patients with Preeclampsia.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe aim of this study was to examine the interaction of Notch/Notch ligand with Th17/Treg, cytokines IL-35 and IL-17 in cases of preeclampsia (PE).
methodsPeripheral blood was obtained from 42 PE patients and 22 health pregnant women. The mRNA expressions of Notch/Notch ligand, Treg transcription factor FoxP3 and Th17 transcription factor RORγt, EBI3 and P35 (IL-35 two subunits), and IL-17 were determined by qPCR. The serum levels of IL-17 and IL-35 were measured by ELISA.
resultsIt was observed that the expressions of Foxp3, EBI3, and P35 in PE patients were lower compared with normal pregnancy, whereas the RORγt expression was significantly increased. The results also demonstrated that PE patients exhibited decreased levels of Treg-related cytokine IL-35, whereas IL-17 was significantly increased. PE patients expressed higher levels of Notch receptor (1-4) and Notch ligand of DLL4, whereas Notch ligand of Jagged-1, -2 was much lower. Furthermore, the levels of FoxP3 T cells correlated positively with Jagged-2. In addition, there were positive correlations between the mRNA level of IL-17 and DLL4.
conclusionOur results indicated that maternal immunological changes may reverse maternal tolerance in PE, and this phenomenon may due to the Th17/Treg imbalance affected by Notch/Notch ligand.
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