Evidence map›Paper›PMID 26074333›Full record

ArticleNature communications2015

mRNA 3'-UTR shortening is a molecular signature of mTORC1 activation.

Jae-Woong Chang, Wei Zhang, Hsin-Sung Yeh, Ebbing P de Jong, Semo Jun, Kwan-Hyun Kim, Sun S Bae, Kenneth Beckman, Tae Hyun Hwang, Kye-Seong Kim and 4 more

Open access · goldAbstract read
PubMed Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 87 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Investigating Potential 5' UTR G-Quadruplexes Within NRF2 mRNA.Current issues in molecular biology · 2026
    Article
  6. Review
  7. PolyA-GLM: A comprehensive framework forComputational and structural biotechnology journal · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. bioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Jae-Woong ChangDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 321 Church Street, SE 6-155 Jackson Hall, Minneapolis, Minnesota 55455, USA.
Wei ZhangDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Hsin-Sung YehDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 321 Church Street, SE 6-155 Jackson Hall, Minneapolis, Minnesota 55455, USA.
Ebbing P de JongDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 321 Church Street, SE 6-155 Jackson Hall, Minneapolis, Minnesota 55455, USA.
Semo JunDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 321 Church Street, SE 6-155 Jackson Hall, Minneapolis, Minnesota 55455, USA.
Kwan-Hyun KimDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 321 Church Street, SE 6-155 Jackson Hall, Minneapolis, Minnesota 55455, USA.
Sun S BaeDepartment of Pharmacology, Pusan National University School of Medicine, Yangsan 626-870, Republic of Korea.
Kenneth BeckmanBiomedical Genomics Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.ORCID 0000000188760706
Tae Hyun HwangQuantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Kye-Seong KimDepartment of Biomedical Science, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 133-791, Republic of Korea.
Do-Hyung KimDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 321 Church Street, SE 6-155 Jackson Hall, Minneapolis, Minnesota 55455, USA.
Timothy J GriffinDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 321 Church Street, SE 6-155 Jackson Hall, Minneapolis, Minnesota 55455, USA.
Rui KuangDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Jeongsik YongDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, 321 Church Street, SE 6-155 Jackson Hall, Minneapolis, Minnesota 55455, USA.
University of Minnesota · USPusan National University · KRThe University of Texas Southwestern Medical Center · US

Funding

Mechanisms of mTOR signaling to early and late stages of autophagyR01GM097057 · NIGMS · UNIVERSITY OF MINNESOTA · PI KIM, DO-HYUNG · 2011 to 2018
$2.7M
ULK, mediator of mTORC1 signaling to agingR21AG039758 · NIA · UNIVERSITY OF MINNESOTA · PI KIM, DO-HYUNG · 2012 to 2013
$403k
NIA NIH HHS AG039758NIGMS NIH HHS GM097057
6 · The paper itself

Abstract

Mammalian target of rapamycin (mTOR) enhances translation from a subset of messenger RNAs containing distinct 5'-untranslated region (UTR) sequence features. Here we identify 3'-UTR shortening of mRNAs as an additional molecular signature of mTOR activation and show that 3'-UTR shortening enhances the translation of specific mRNAs. Using genetic or chemical modulations of mTOR activity in cells or mouse tissues, we show that cellular mTOR activity is crucial for 3'-UTR shortening. Although long 3'-UTR-containing transcripts minimally contribute to translation, 3-'UTR-shortened transcripts efficiently form polysomes in the mTOR-activated cells, leading to increased protein production. Strikingly, selected E2 and E3 components of ubiquitin ligase complexes are enriched by this mechanism, resulting in elevated levels of protein ubiquitination on mTOR activation. Together, these findings identify a previously uncharacterized role for mTOR in the selective regulation of protein synthesis by modulating 3'-UTR length of mRNAs.

Indexed as

3' Untranslated RegionsRNA Processing, Post-TranscriptionalAnimalsBlotting, WesternFibroblastsGene Expression RegulationMass SpectrometryMechanistic Target of Rapamycin Complex 1MiceMultiprotein ComplexesPolyribosomesProtein BiosynthesisRNA, MessengerTOR Serine-Threonine KinasesUbiquitinationUbiquitin-Conjugating Enzymes3' Untranslated RegionsMechanistic Target of Rapamycin Complex 1mTOR protein, mouseMultiprotein ComplexesRNA, MessengerTOR Serine-Threonine KinasesUbiquitin-Conjugating EnzymesUbiquitin-Protein Ligases

Identifiers

PMID26074333
OpenAlexW2254187956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.