Evidence map›Paper›PMID 26074200›Full record

ArticleNeuroImage2015

Multi-level block permutation.

Anderson M Winkler, Matthew A Webster, Diego Vidaurre, Thomas E Nichols, Stephen M Smith

Open access · hybridAbstract read
In one paragraph

Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 276 citations in OpenAlex.

  1. Trial
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  6. Brain morphometry patterns in the presence of Alzheimer's disease and/or LATE neuropathologic changes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  7. Review
  8. The intrinsic cortical geometry of reading.bioRxiv : the preprint server for biology · 2026
    Article
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  12. ADHD symptom trajectories and brain morphometry: A longitudinal analysis.medRxiv : the preprint server for health sciences · 2026
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108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anderson M WinklerOxford Centre for Functional MRI of the Brain, University of Oxford, Oxford, UK. Electronic address: winkler@fmrib.ox.ac.uk.
Matthew A WebsterOxford Centre for Functional MRI of the Brain, University of Oxford, Oxford, UK.
Diego VidaurreOxford Centre for Human Brain Activity, University of Oxford, Oxford, UK.
Thomas E NicholsOxford Centre for Functional MRI of the Brain, University of Oxford, Oxford, UK; Department of Statistics & Warwick Manufacturing Group, University of Warwick, Coventry, UK.
Stephen M SmithOxford Centre for Functional MRI of the Brain, University of Oxford, Oxford, UK.
University of Oxford · GBUniversity of Warwick · GB

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Medical Research Council G0900908NIBIB NIH HHS R01 EB015611NIBIB NIH HHS R01 EB015611-01NIMH NIH HHS 1U54MH091657NIMH NIH HHS U54 MH091657Wellcome Trust 00309/Z/12/ZWellcome Trust 098369Wellcome Trust 100309
6 · The paper itself

Abstract

Under weak and reasonable assumptions, mainly that data are exchangeable under the null hypothesis, permutation tests can provide exact control of false positives and allow the use of various non-standard statistics. There are, however, various common examples in which global exchangeability can be violated, including paired tests, tests that involve repeated measurements, tests in which subjects are relatives (members of pedigrees) - any dataset with known dependence among observations. In these cases, some permutations, if performed, would create data that would not possess the original dependence structure, and thus, should not be used to construct the reference (null) distribution. To allow permutation inference in such cases, we test the null hypothesis using only a subset of all otherwise possible permutations, i.e., using only the rearrangements of the data that respect exchangeability, thus retaining the original joint distribution unaltered. In a previous study, we defined exchangeability for blocks of data, as opposed to each datum individually, then allowing permutations to happen within block, or the blocks as a whole to be permuted. Here we extend that notion to allow blocks to be nested, in a hierarchical, multi-level definition. We do not explicitly model the degree of dependence between observations, only the lack of independence; the dependence is implicitly accounted for by the hierarchy and by the permutation scheme. The strategy is compatible with heteroscedasticity and variance groups, and can be used with permutations, sign flippings, or both combined. We evaluate the method for various dependence structures, apply it to real data from the Human Connectome Project (HCP) as an example application, show that false positives can be avoided in such cases, and provide a software implementation of the proposed approach.

Indexed as

AdultAlgorithmsCerebral CortexConnectomeData Interpretation, StatisticalFemaleHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance ImagingMaleReproducibility of ResultsStatistics, NonparametricYoung AdultGeneral linear modelMultiple regressionPermutation inferenceRepeated measurements

Identifiers

PMID26074200
PMCPMC4644991
OpenAlexW1606491053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.