ArticleScientific reports2015
Network nanostructured polypyrrole hydrogel/Au composites as enhanced electrochemical biosensing platform.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 112 citations in OpenAlex.
- Nitrogen-doped carbon nano-onions/polypyrrole nanocomposite based low-cost flexible sensor for room temperature ammonia detection.Scientific reports · 2024Article
- Hydrogel Bioelectronics for Health Monitoring.Biosensors · 2023Review
- Application of Polypyrrole-Based Electrochemical Biosensor for the Early Diagnosis of Colorectal Cancer.Nanomaterials (Basel, Switzerland) · 2023Review
- Nano-Scaled Materials and Polymer Integration in Biosensing Tools.Biosensors · 2022Review
- Conductive Gels: Properties and Applications of Nanoelectronics.Nanoscale research letters · 2022Review
- Zwitterionic Polymer Electroplating Facilitates the Preparation of Electrode Surfaces for Biosensing.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Article
- An Electrochemical Aptasensor for PbBiosensors · 2020Article
- Advancements in Hydrogel-Functionalized Immunosensing Platforms.ACS omega · 2020Review
- Nanomaterials for Healthcare Biosensing Applications.Sensors (Basel, Switzerland) · 2019Review
- Progress in the Development of Intrinsically Conducting Polymer Composites as Biosensors.Macromolecular chemistry and physics · 2019Review
- Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications.Polymers · 2019Review
- Ionic Liquid-Polypyrrole-Gold Composites as Enhanced Enzyme Immobilization Platforms for Hydrogen Peroxide Sensing.Sensors (Basel, Switzerland) · 2019Article
- Antifouling (Bio)materials for Electrochemical (Bio)sensing.International journal of molecular sciences · 2019Review
- Nanocomposite Hydrogels: Advances in Nanofillers Used for Nanomedicine.Gels (Basel, Switzerland) · 2018Review
- Sulfobetaine methacrylate hydrogel-coated anti-fouling surfaces for implantable biomedical devices.Biomaterials research · 2018Article
- Globular Shaped Polypyrrole Doped Well-Dispersed Functionalized Multiwall Carbon Nanotubes/Nafion Composite for Enzymatic Glucose Biosensor Application.Scientific reports · 2017Article
- Multifunctional substrate of label-free electrochemical immunosensor for ultrasensitive detection of cytokeratins antigen 21-1.Scientific reports · 2017Article
- Polyhydroquinone-graphene composite as new redox species for sensitive electrochemical detection of cytokeratins antigen 21-1.Scientific reports · 2016Article
- A novel electrochemical nanobiosensor for the ultrasensitive and specific detection of femtomolar-level gastric cancer biomarker miRNA-106a.Beilstein journal of nanotechnology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, a new network nanocomposite composed of polypyrrole hydrogel (PPy hydrogel) loaded gold nanoparticles (AuNPs) was prepared. The PPy hydrogel was directly synthesized by mixing the pyrrole monomer and phytic acid, and the mixed solution can be gelated to form hydrogel at once. The three-dimensional network nanostructured PPy hydrogel not only provided a greater effective surface area for increasing the quantity of immobilized biomolecules and facilitated the transport of electrons and ions, but also exhibited an improved conductivity. Meanwhile, the electrodeposited AuNPs on the PPy hydrogel can further increase the specific surface area to capture a large amount of antibodies as well as improve the capability of electron transfer. The network PPy hydrogel/Au nanocomposites were successfully employed for the fabrication of a sensitive label-free amperometric immunosensor. Carcinoembryonic antigen (CEA) was used as a model protein. The proposed immunosensor exhibited a wide linear detection range from 1 fg mL(-1) to 200 ng mL(-1), and an ultralow limit of detection of 0.16 g mL(-1) (S/N = 3), and it also possessed good selectivity. Moreover, the detection of CEA in ten human serums showed satisfactory accuracy compared with the data determined by ELISA, indicating that the immunosensor provided potential application for clinical diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.