Evidence map›Paper›PMID 26073884›Full record

ArticleNature communications2015

Multiple independent autonomous hydraulic oscillators driven by a common gravity head.

Sung-Jin Kim, Ryuji Yokokawa, Sasha Cai Lesher-Perez, Shuichi Takayama

Abstract read
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Periodic Flows in Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  3. Review
  4. Article
  5. CMOS-Inspired Complementary Fluidic Circuits for Soft Robots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  6. Article
  7. Digital logic for soft devices.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sung-Jin Kim1] Department of Mechanical Engineering, Konkuk University, Seoul 143-701, Republic of Korea [2] Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Ryuji Yokokawa1] Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA [2] Department of Micro Engineering, Kyoto University, Kyoto 615-8540, Japan.
Sasha Cai Lesher-PerezDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Shuichi Takayama1] Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA [2] Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA [3] Biointerfaces Institute, 2800 Plymouth Road, NCRC Building 10 A183, Ann Arbor, Michigan 48109, USA [4] University of Michigan Center for Integrative Research in Critical Care (MCIRCC), Building 10-103A, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, Michigan 48109, USA.

Funding

Cellular Biotechnology Training Program (CBTP)T32GM008353 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, ANNA · 1991 to 2021
$9.3M
Microfluidic Analysis of Oscillatory Signaling Pathways Using Phase LockingR01GM096040 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAKAYAMA, SHUICHI · 2011 to 2014
$1.1M
NIGMS NIH HHS GM 096040NIGMS NIH HHS R01 GM096040NIGMS NIH HHS T32 GM008353
6 · The paper itself

Abstract

Self-switching microfluidic circuits that are able to perform biochemical experiments in a parallel and autonomous manner, similar to instruction-embedded electronics, are rarely implemented. Here, we present design principles and demonstrations for gravity-driven, integrated, microfluidic pulsatile flow circuits. With a common gravity head as the only driving force, these fluidic oscillator arrays realize a wide range of periods (0.4 s-2 h) and flow rates (0.10-63 μl min(-1)) with completely independent timing between the multiple oscillator sub-circuits connected in parallel. As a model application, we perform systematic, parallel analysis of endothelial cell elongation response to different fluidic shearing patterns generated by the autonomous microfluidic pulsed flow generation system.

Indexed as

GravitationMicrofluidicsPulsatile FlowComputer SimulationEndothelial CellsEquipment DesignHumansHuman Umbilical Vein Endothelial CellsShear StrengthStress, Mechanical

Identifiers

PMID26073884
PMCPMC4470298

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.