ReviewTranslational stroke research2015
The Pathophysiology of Intracerebral Hemorrhage Formation and Expansion.
Review in Translational stroke research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.
- Effects of subarachnoid extension following intracerebral hemorrhage: A systematic review and meta-analysis.Medicine · 2022Pooled it
- Convolutional Neural Network in Microsurgery Treatment of Spontaneous Intracerebral Hemorrhage.Computational and mathematical methods in medicine · 2022Trial
- Notoginsenoside R1 Attenuates Oxidative Damage After Intracerebral Hemorrhage by Inhibiting LCN2 and Promoting HO-1 in Astrocytes.Brain sciences · 2026Article
- Temporal Profile of Soluble TLR4 and its Association with Intracerebral Haemorrhage Expansion.Translational stroke research · 2026Article
- Associations between Hematoma Density, Hematoma Evacuation Efficacy, and In-Hospital Mortality in Patients Undergoing Minimally Invasive Surgery after Intracerebral Hemorrhage.Neurocritical care · 2026Article
- High systolic blood pressure variability is associated with impaired cerebral autoregulation and poor functional recovery after intracerebral hemorrhage.Scientific reports · 2026Article
- Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case-Control Study.Annals of clinical and translational neurology · 2026Article
- Ultra-early computed tomography markers of haematoma expansion: Potential trial targets?European stroke journal · 2026Article
- A novel dose-dependent predictor for hematoma expansion on non-contrast CT: the number of black hole signs in spontaneous intracerebral hemorrhage.Neurosurgical review · 2025Article
- Temporal evolution of non-contrast CT markers of expansion relates to the dynamics of acute intracerebral hemorrhage.Neuroradiology · 2025Observational
- Clinical and Radiological Predictors for Early Hematoma Expansion After Spontaneous Intracerebral Hemorrhage: A Retrospective Study.Neurology international · 2025Article
- The involvement of 5-HT was necessary for EA-mediated improvement of post-stroke depression.Translational psychiatry · 2025Article
- Stealth hemostatic anchors with vWF-driven navigation and plasmin-triggered tranexamic release for hematoma containment in cerebral hemorrhage.Asian journal of pharmaceutical sciences · 2025Article
- Lower high-density lipoprotein cholesterol level is associated with hematoma expansion in acute intracerebral hemorrhage: association with hypertensive microangiopathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Mitochondrial Quality Control: Insights into Intracerebral Hemorrhage.Cellular and molecular neurobiology · 2025Review
- Ultra-early computed tomography markers of haematoma expansion: Potential trial targets?European stroke journal · 2025Article
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- The Role of ICP Monitoring in Minimally Invasive Surgery for the Management of Intracerebral Hemorrhage.Translational stroke research · 2025Review
- Extracellular Vesicles as a Potential Therapy for Stroke.International journal of molecular sciences · 2025Review
- Brain Atrophy Is Associated with Hematoma Expansion in Intracerebral Hemorrhage, Depending on Coagulation Status.Journal of clinical medicine · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracerebral hemorrhage is a devastating disease. Despite its clinical importance, the pathophysiology of intracerebral hemorrhage is not well understood. Hematoma expansion occurs in a large subset of patients and is a predictor of poor outcomes. Since hematoma growth provides a potential opportunity for therapeutic intervention, a thorough understanding of its biological mechanisms is of key importance. After vessel rupture, an initial hematoma forms. Following this initial phase, accumulating evidence suggests that the mass effect causes secondary vessel rupture, which contributes to the hematoma and may trigger an avalanche of further vessel ruptures. The circumstances under which this occurs and to what extent secondary hemorrhage contributes to final hematoma volume remain unknown, however. To address these questions, a translational approach seems most suitable. Current experimental models include intracranial injections of collagenase or autologous blood. Each has individual strengths and weaknesses in its ability to simulate human intracerebral hemorrhage. The ultimate goal for improved understanding and modeling of the pathophysiology of hematoma expansion is to identify new treatment approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.