ArticleScientific reports2015
Insights into the Transcriptional Architecture of Behavioral Plasticity in the Honey Bee Apis mellifera.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Meta-analysis of honey bee neurogenomic response links Deformed wing virus type A to precocious behavioral maturation.Scientific reports · 2020Pooled it
- Differential expression of neuronal function genes follows a tissue-specific temporal dynamic during Deformed Wing Virus infection in honey bees.Scientific reports · 2026Article
- Genome-Wide Identification of Transcriptional Start Sites and Candidate Enhancers Regulating Worker Metamorphosis inInsects · 2026Article
- Variation in behavioural maturation in tropical honey bees corresponds with hormonal and molecular differences.The Journal of experimental biology · 2026Article
- Article
- Transcriptional responses in feeder time-trained foragers suggest diverse interactions between the circadian clock and mushroom bodies in honey bees.Scientific reports · 2025Article
- Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees.Nature communications · 2025Article
- Article
- Effects of microRNA-305 knockdown on brain gene expression associated with division of labor in honey bee colonies (Apis mellifera).The Journal of experimental biology · 2024Article
- Brain Gene Expression of Foraging Behavior and Social Environment in Ceratina calcarata.Genome biology and evolution · 2023Article
- Histone acetyltransferases and external demands influence task switching inBiology letters · 2023Article
- Evolutionary Invariant of the Structure of DNA Double Helix in RNAP II Core Promoters.International journal of molecular sciences · 2022Article
- Social divergence: molecular pathways underlying castes and longevity in a facultatively eusocial small carpenter bee.Proceedings. Biological sciences · 2022Article
- Missing Nurse Bees-Early Transcriptomic Switch From Nurse Bee to Forager Induced by Sublethal Imidacloprid.Frontiers in genetics · 2021Article
- The nuclear and mitochondrial genomes of Frieseomelitta varia - a highly eusocial stingless bee (Meliponini) with a permanently sterile worker caste.BMC genomics · 2020Article
- Immediate early gene kakusei potentially plays a role in the daily foraging of honey bees.PloS one · 2020Article
- Social modularity: conserved genes and regulatory elements underlie caste-antecedent behavioural states in an incipiently social bee.Proceedings. Biological sciences · 2019Article
- Honey bee (Apis mellifera) larval pheromones may regulate gene expression related to foraging task specialization.BMC genomics · 2019Article
- Division of labor in honey bees is associated with transcriptional regulatory plasticity in the brain.The Journal of experimental biology · 2019Article
- lncRNA profile of Apis mellifera and its possible role in behavioural transition from nurses to foragers.BMC genomics · 2019Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Honey bee colonies exhibit an age-related division of labor, with worker bees performing discrete sets of behaviors throughout their lifespan. These behavioral states are associated with distinct brain transcriptomic states, yet little is known about the regulatory mechanisms governing them. We used CAGEscan (a variant of the Cap Analysis of Gene Expression technique) for the first time to characterize the promoter regions of differentially expressed brain genes during two behavioral states (brood care (aka "nursing") and foraging) and identified transcription factors (TFs) that may govern their expression. More than half of the differentially expressed TFs were associated with motifs enriched in the promoter regions of differentially expressed genes (DEGs), suggesting they are regulators of behavioral state. Strikingly, five TFs (nf-kb, egr, pax6, hairy, and clockwork orange) were predicted to co-regulate nearly half of the genes that were upregulated in foragers. Finally, differences in alternative TSS usage between nurses and foragers were detected upstream of 646 genes, whose functional analysis revealed enrichment for Gene Ontology terms associated with neural function and plasticity. This demonstrates for the first time that alternative TSSs are associated with stable differences in behavior, suggesting they may play a role in organizing behavioral state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.