ArticleThe American journal of pathology2015
Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin.
Article in The American journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Organization of a cytoskeletal superstructure in the apical domain of intestinal tuft cells.The Journal of cell biology · 2024Article
- Impact of autoimmune gastritis on chronic urticaria in paediatric patients - pathophysiological point of views.European journal of pediatrics · 2024Review
- Dynamic tuft cell expansion during gastric metaplasia and dysplasia.The journal of pathology. Clinical research · 2024Article
- A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development.Nature communications · 2023Article
- Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity.JCI insight · 2023Article
- LRIG1, a regulator of stem cell quiescence and a pleiotropic feedback tumor suppressor.Seminars in cancer biology · 2022Review
- Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond.Gastroenterology · 2022Review
- Group 2 Innate Lymphoid Cells Coordinate Damage Response in the Stomach.Gastroenterology · 2020Article
- The Physiology of the Gastric Parietal Cell.Physiological reviews · 2020Review
- LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.Nature communications · 2019Article
- Evaluation of Lineage Changes in the Gastric Mucosa Following Infection WithThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach.Gastroenterology · 2018Article
- Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro.Scientific reports · 2018Article
- Luminal chemosensing in the gastroduodenal mucosa.Current opinion in gastroenterology · 2017Review
- Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity.JCI insight · 2017Article
- Unique Cellular Lineage Composition of the First Gland of the Mouse Gastric Corpus.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Epithelial Regeneration After Gastric Ulceration Causes Prolonged Cell-Type Alterations.Cellular and molecular gastroenterology and hepatology · 2016Article
- Regulatory Roles of Dclk1 in Epithelial Mesenchymal Transition and Cancer Stem Cells.Journal of carcinogenesis & mutagenesis · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Doublecortin-like kinase 1 (Dclk1) is considered a reliable marker for tuft cells in the gastrointestinal tract. We investigated the dynamic changes of tuft cells associated with mouse models of oxyntic atrophy and metaplasia in the stomach. Increases in the numbers of Dclk1-positive tuft cells were observed in several models of parietal cell loss. However, the expanded population of Dclk1-expressing cells showed a morphologically distinct structure in apical microvilli and acetylated microtubules, which was not seen in the tuft cells present in the normal gastric mucosa. These microvillar sensory cells (MVSCs) showed no evidence of proliferation. The expansion of the MVSCs induced by oxyntic atrophy was reversible after the return of parietal cells. More important, expansion of MVSCs after induced parietal cell loss was not observed in Gast(-/-) mice. Although the Dclk1-expressing cells in the normal gastric mucosa were in part derived from Lrig1-expressing stem cells, the Lrig1-lineaged cells did not produce the expanded Dclk1-expressing cells associated with oxyntic atrophy. These studies indicate that loss of parietal cells leads to the reversible emergence of a novel Dclk1-expressing sensory cell population in the gastric mucosa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.