Evidence map›Paper›PMID 26072707›Full record

ArticleScientific reports2015

Morphine compromises bronchial epithelial TLR2/IL17R signaling crosstalk, necessary for lung IL17 homeostasis.

Santanu Banerjee, Jana Ninkovic, Jingjing Meng, Umakant Sharma, Jing Ma, Richard Charboneau, Sabita Roy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
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  7. Article
  8. Microbiota-activated CD103Microbiome · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Santanu BanerjeeSurgery, Basic and Translational Research, University of Minnesota, 515 Delaware St SE, Minneapolis, MN, USA.
Jana NinkovicSurgery, Basic and Translational Research, University of Minnesota, 515 Delaware St SE, Minneapolis, MN, USA.
Jingjing MengPharmacology, University of Minnesota, 321 Church St SE, Minneapolis, MN, USA.
Umakant SharmaSurgery, Basic and Translational Research, University of Minnesota, 515 Delaware St SE, Minneapolis, MN, USA.
Jing MaSurgery, Basic and Translational Research, University of Minnesota, 515 Delaware St SE, Minneapolis, MN, USA.
Richard CharboneauSurgery, Basic and Translational Research, University of Minnesota, 515 Delaware St SE, Minneapolis, MN, USA.
Sabita RoySurgery, Basic and Translational Research, University of Minnesota, 515 Delaware St SE, Minneapolis, MN, USA.
University of Minnesota · US

Funding

Subcellular Targeting/Packaging of Opioids/ReceptorsP50DA011806 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOH, HORACE · 1998 to 2012
$14.0M
Opioid Abuse, opportunistic infection and NeuroAIDSR01DA012104 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROY, SABITA · 1999 to 2013
$3.7M
Gut microbiota disruption by Morphine and in the context of HIV infection contributes to sustained immune activationR01DA037843 · NIDA · UNIVERSITY OF MINNESOTA · PI JOHNSON, TIMOTHY J, ROY, SABITA · 2014 to 2018
$2.8M
Morphine, HIV proteins, wound healing and InfectionR01DA022935 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2007 to 2011
$1.7M
Role of microRNAs in opioid drug abuse induced persistent Inflammation and HIV diR01DA031202 · NIDA · UNIVERSITY OF MINNESOTA · PI RAMAKRISHNAN, SUNDARAM, ROY, SABITA · 2011 to 2015
$1.7M
Mechanism underlying Morphine modulation of gut barrier function in the Context oR01DA034582 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2013 to 2017
$1.6M
Opioid Drug abuse in the context of opportunistic infection increases susceptibilK05DA033881 · NIDA · UNIVERSITY OF MINNESOTA · PI ROY, SABITA · 2012 to 2016
$661k
HIV and Morphine Increase Susceptibility to Lung Opportunistic Infections by Modulating TLR2/IL17A Mediated Lung InflammationR21HL125021 · NHLBI · UNIVERSITY OF MINNESOTA · PI BANERJEE, SANTANU · 2015 to 2016
$420k
NHLBI NIH HHS R21 HL125021NIDA NIH HHS 1R01DA034582NIDA NIH HHS K05 DA033881NIDA NIH HHS K05DA033881NIDA NIH HHS P50 DA011806NIDA NIH HHS R01 DA012104NIDA NIH HHS R01 DA022935NIDA NIH HHS R01 DA031202NIDA NIH HHS R01 DA034582NIDA NIH HHS R01 DA037843NIDA NIH HHS R01 DA12104
6 · The paper itself

Abstract

Opportunistic lung infection and inflammation is a hallmark of chronic recreational/clinical use of morphine. We show that early induction of IL17 from the bronchial epithelium, following pathogenic encounter is a protective response, which contributes to pathogenic clearance and currently attributed to TLR2 activation in immune cells. Concurrent activation of TLR2 and IL17R in bronchial epithelium results in the sequestration of MyD88 (TLR2 adapter) by Act1/CIKS (IL17R adapter), thereby turning off TLR2 signaling to restore homeostasis. Morphine inhibits the early IL17 release and interaction between Act1 and MyD88, leading to decreased pathogenic clearance and sustained inflammation. Hence, we propose that therapeutically targeting either TLR2 or IL17 in bronchial epithelia, in the context of morphine, can restore inflammatory homeostasis.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsGene Expression RegulationHomeostasisHumansInflammationInterleukin-17LungMaleMiceMice, Inbred C57BLMice, KnockoutMorphineMyeloid Differentiation Factor 88Pneumococcal InfectionsReceptor Cross-TalkAdaptor Proteins, Signal TransducingInterleukin-17MorphineMyd88 protein, mouseMyeloid Differentiation Factor 88Receptors, Interleukin-17Receptors, Opioid, muTlr2 protein, mouseTlr4 protein, mouseToll-Like Receptor 2Toll-Like Receptor 4Traf3ip2 protein, mouse

Identifiers

PMID26072707
PMCPMC4466887
OpenAlexW594161008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.