Evidence map›Paper›PMID 26072452›Full record

ReviewTrends in genetics : TIG2015

Revisiting classic clines in Drosophila melanogaster in the age of genomics.

Jeffrey R Adrion, Matthew W Hahn, Brandon S Cooper

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Article
  2. Temperature-sensitive cytoplasmic incompatibility across divergentbioRxiv : the preprint server for biology · 2026
    Article
  3. Early life-stage thermal resilience is determined by climate-linked regulatory variation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeffrey R AdrionDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Matthew W HahnDepartment of Biology, Indiana University, Bloomington, IN 47405, USA; School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA.
Brandon S CooperCenter for Population Biology, University of California, Davis, CA 95616, USA; Department of Evolution and Ecology, University of California, Davis, CA 95616, USA. Electronic address: bscooper@ucdavis.edu.

Funding

TRAINING IN GENETICST32GM007757 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI KUMAR, JUSTIN P · 1985 to 2014
$8.1M
Identifying contexts that improve Wolbachia as a biocontrol of vector-borne diseaF32AI114176 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COOPER, BRANDON S. · 2014 to 2016
$158k
NIAID NIH HHS F32 AI114176NIAID NIH HHS F32-AI114176NIGMS NIH HHS T32 GM007757NIGMS NIH HHS T32-GM007757
6 · The paper itself

Abstract

Adaptation to spatially varying environments has been studied for decades, but advances in sequencing technology are now enabling researchers to investigate the landscape of genetic variation underlying this adaptation genome wide. In this review we highlight some of the decades-long research on local adaptation in Drosophila melanogaster from well-studied clines in North America and Australia. We explore the evidence for parallel adaptation and identify commonalities in the genes responding to clinal selection across continents as well as discussing instances where patterns differ among clines. We also investigate recent studies utilizing whole-genome data to identify clines in D. melanogaster and several other systems. Although connecting segregating genomic variation to variation in phenotypes and fitness remains challenging, clinal genomics is poised to increase our understanding of local adaptation and the selective pressures that drive the extensive phenotypic diversity observed in nature.

Indexed as

EcosystemGenomicsAnimalsDrosophila melanogasterGenetic VariationGenome, InsectPhenotypelatitudinal clinelocal adaptationspatially varying selection

Identifiers

PMID26072452
PMCPMC4526433

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.