Trial reportClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016
Finger force changes in the absence of visual feedback in patients with Parkinson's disease.
Trial report in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06435078 (Developments of Novel Virtual Visual and Haptic Stimulation Systems for the Elderly), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developments of Novel Virtual Visual and Haptic Stimulation Systems for the Elderly
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Clinical assessment of upper limb impairments and functional capacity in Parkinson's disease: a systematic review.Arquivos de neuro-psiquiatria · 2023Pooled it
- Force production with a subset of fingers: two aspects of unintentional finger involvement.Experimental brain research · 2026Article
- Stability of performance in a hierarchical system during isometric force production and effects of visual feedback.Experimental brain research · 2025Article
- Force matching: motor effects that are not reported by the actor.Experimental brain research · 2024Article
- Unintentional force drifts in the lower extremities.Experimental brain research · 2023Article
- Higher visual gain contributions to bilateral motor synergies and force control.Scientific reports · 2022Article
- Perturbation-induced fast drifts in finger enslaving.Experimental brain research · 2021Article
- Torque variability of the plantar flexors in people with Huntington's disease.American journal of translational research · 2021Article
- On the origin of finger enslaving: control with referent coordinates and effects of visual feedback.Journal of neurophysiology · 2020Article
- Case Studies in Neuroscience: The central and somatosensory contributions to finger interdependence and coordination: lessons from a study of a "deafferented person".Journal of neurophysiology · 2019Article
- Real-time slacking as a default mode of grip force control: implications for force minimization and personal grip force variation.Journal of neurophysiology · 2018Article
- Stability of hand force production. II. Ascending and descending synergies.Journal of neurophysiology · 2018Article
- Performance drifts in two-finger cyclical force production tasks performed by one and two actors.Experimental brain research · 2018Article
- Improvement in upper-limb UPDRS motor scores following fast-paced arm exercise: A pilot study.Restorative neurology and neuroscience · 2018Article
- Force illusions and drifts observed during muscle vibration.Journal of neurophysiology · 2018Article
- Welding-related brain and functional changes in welders with chronic and low-level exposure.Neurotoxicology · 2018Article
- Stability of hand force production. I. Hand level control variables and multifinger synergies.Journal of neurophysiology · 2017Article
- Unintentional drifts during quiet stance and voluntary body sway.Experimental brain research · 2017Article
- Unintentional force changes in cyclical tasks performed by an abundant system: Empirical observations and a dynamical model.Neuroscience · 2017Article
- Optimality and stability of intentional and unintentional actions: I. Origins of drifts in performance.Experimental brain research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe investigated the unintentional drift in total force and in sharing of the force between fingers in two-finger accurate force production tasks performed without visual feedback by patients with Parkinson's disease (PD) and healthy controls. In particular, we were testing a hypothesis that adaptation to the documented loss of action stability could lead to faster force drop in PD.
methodsPD patients and healthy controls performed accurate constant force production tasks without visual feedback by different finger pairs, starting with different force levels and different sharing patterns of force between the two fingers.
resultsBoth groups showed an exponential force drop with time and a drift of the sharing pattern towards 50:50. The PD group showed a significantly faster force drop without a change in speed of the sharing drift. These results were consistent across initial force levels, sharing patterns, and finger pairs. A pilot test of four subjects, two PD and two controls, showed no consistent effects of memory on the force drop.
conclusionsWe interpret the force drop as a consequence of back-coupling between the actual and referent finger coordinates that draws the referent coordinate towards the actual one. The faster force drop in the PD group is interpreted as adaptive to the loss of action stability in PD. The lack of group differences in the sharing drift suggests two potentially independent physiological mechanisms contributing to the force and sharing drifts. SIGNIFICANCE: The hypothesis on adaptive changes in PD with the purpose to ensure stability of steady states may have important implications for treatment of PD. The speed of force drop may turn into a useful tool to quantify such adaptive changes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.