ArticleDigestive diseases and sciences2015
The Incidence, Predictors and Outcomes of Gastrointestinal Bleeding in Patients with Left Ventricular Assist Device (LVAD).
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Gastrointestinal bleeding in recipients of left ventricular assist devices-a systematic review.Heart failure reviews · 2023Pooled it
- Enhancing Left Ventricular Assist Device Usability: A Comparative Simulation Study of CorWave and HeartMate 3 Peripherals.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Active and passive cardiac indexes as complementary predictors of outcomes after left ventricular assist device implantation.The Journal of thoracic and cardiovascular surgery · 2026Article
- Left Ventricular Assist Device in the Management of Heart Failure: A Single-Center Experience.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025Article
- Gastrointestinal Bleeding During Long-Term Left Ventricular Assist Device Support: External Validation of UTAH Bleeding Risk Score.Journal of cardiovascular development and disease · 2025Article
- Pre- and Post-Implant Endoscopy in Left Ventricular Assist Device Recipients: A Single-Center Experience.Gastroenterology research · 2024Article
- Partial Pressure of End-Tidal Oxygen and Blood Lactate During Cardiopulmonary Exercise Testing in Healthy Older Participants and Patients at Risk of Cardiac Disease.Cardiology research · 2024Article
- Quantitative Assessment of Aortic Hemodynamics for Varying Left Ventricular Assist Device Outflow Graft Angles and Flow Pulsation.Annals of biomedical engineering · 2023Article
- Role of octreotide in small bowel bleeding.World journal of clinical cases · 2022Review
- Intravenous administration of umbilical cord lining stem cells in left ventricular assist device recipient: Rationale and design of the uSTOP LVAD BLEED pilot study.American heart journal plus : cardiology research and practice · 2022Article
- Utility of Endoscopy in Hospitalized Patients with Gastrointestinal Hemorrhage and Pulmonary Hypertension.Digestive diseases and sciences · 2021Article
- Treatment of gastrointestinal bleeding in left ventricular assist devices: A comprehensive review.World journal of gastroenterology · 2020Review
- Outcomes of gastrointestinal bleeding in patients with left ventricular assist devices: a tertiary care experience.Endoscopy international open · 2020Article
- Clinical Approach to Manage Gastrointestinal Bleeding with a Left Ventricular Assist Device (LVAD).Cureus · 2019Review
- Bleeding in critical care associated with left ventricular assist devices: pathophysiology, symptoms, and management.Hematology. American Society of Hematology. Education Program · 2019Article
- Comparative Analysis of Established Risk Scores and Novel Hemodynamic Metrics in Predicting Right Ventricular Failure in Left Ventricular Assist Device Patients.Journal of cardiac failure · 2019Article
- Optimal haemodynamics during left ventricular assist device support are associated with reduced haemocompatibility-related adverse events.European journal of heart failure · 2019Article
- Preoperative Right-Sided Cardiac Congestion Is Associated with Gastrointestinal Bleeding in Patients with Continuous-Flow Left Ventricular Assist Devices.Digestive diseases and sciences · 2018Article
- Gastrointestinal Hemorrhage in Left Ventricular Assist Device Patients: Red Scare or Pressure from the Right?Digestive diseases and sciences · 2018Article
- Long-Acting Octreotide Reduces the Recurrence of Gastrointestinal Bleeding in Patients With a Continuous-Flow Left Ventricular Assist Device.Journal of cardiac failure · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate rate, recurrence, and predictors of gastrointestinal bleeding (GIB) and impact of endoscopy in left ventricular assist device (LVAD) patients.
methodsThis is a cohort study of all patients who received the current-generation continuous-flow HeartMate II LVAD from 2005 to 2013 at our institution. Patients were followed up, and GIB events recorded until death, time of heart transplantation, or end of observation.
resultsLVAD was implanted in 112 patients (median age 67 years, 88% male). A total of 44 patients (39%) had 74 GIB events occurring at a rate of 42.9 per 100 p-y. Endoscopy was performed in 77% of patients, and GIB source was identified in 57% with upper GIB found in almost two-third of cases. Right ventricular dysfunction and post-LVAD ejection fraction >30% were associated with higher GIB rates. Higher pulsatility index was associated with lower GIB rates. Re-bleeding occurred in 19 (43%) patients at a rate of 62.5 per 100 p-y and was not affected by endoscopic therapy at the index endoscopy.
conclusionsGIB in LVAD patients is common, occurring primarily in the upper GI tract. Upper endoscopy is the preferred strategy though lower endoscopy is also recommended for a full workup. Endoscopy can identify GIB lesions in about 50% of patients, but re-bleeding is common. Right ventricular dysfunction and post-LVAD ejection fraction >30% are associated with higher GIB rates. Higher pulsatility index is associated with lower GIB rates. Reduction in pump speed is a potential strategy for managing and preventing GIB.
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