ReviewProgress in brain research2015
Major diencephalic inputs to the hippocampus: supramammillary nucleus and nucleus reuniens. Circuitry and function.
Review in Progress in brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Response Flexibility: The Role of the Lateral Habenula.Frontiers in behavioral neuroscience · 2022Pooled it
- Article
- Developmental CA2 perineuronal net reduction restores social memory in Shank3 mutant mice.Communications biology · 2026Article
- Hippocampo-supramammillary coupling across sleep and wake.Scientific reports · 2026Article
- Review
- Article
- Developmental CA2 perineuronal net reduction restores social memory inbioRxiv : the preprint server for biology · 2025Article
- Primary age-related tauopathy.Acta neuropathologica · 2025Review
- Different frequencies of human scalp-recorded theta activity may index integration of activity in distinct recurrent cortico-subcortical mnemonic networks.Frontiers in behavioral neuroscience · 2025Review
- Hypothalamic regulation of hippocampal CA1 interneurons by the supramammillary nucleus.Cell reports · 2024Article
- Contributions of site- and sex-specific LTPs to everyday memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits.Communications biology · 2024Article
- Review
- Dopamine D4 Receptor Agonist Drastically Increases Delta Activity in the Thalamic Nucleus Reuniens: Potential Role in Communication between Prefrontal Cortex and Hippocampus.International journal of molecular sciences · 2023Article
- Hypothalamic Supramammillary Nucleus Selectively Excites Hippocampal CA3 Interneurons to Suppress CA3 Pyramidal Neuron Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Uncorrelated bilateral cortical input becomes timed across hippocampal subfields for long waves whereas gamma waves are largely ipsilateral.Frontiers in cellular neuroscience · 2023Article
- The evolutionary origins of the Global Neuronal Workspace in vertebrates.Neuroscience of consciousness · 2023Review
- Neuropeptides and small-molecule amine transmitters: cooperative signaling in the nervous system.Cellular and molecular life sciences : CMLS · 2022Review
- Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior.Nature neuroscience · 2022Article
- Optogenetics: implications for Alzheimer's disease research and therapy.Molecular brain · 2022Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The hippocampus receives two major external inputs from the diencephalon, that is, from the supramammillary nucleus (SUM) and nucleus reuniens (RE) of the midline thalamus. These two afferents systems project to separate, nonoverlapping, regions of the hippocampus. Specifically, the SUM distributes to the dentate gyrus (DG) and to CA2 of the dorsal and ventral hippocampus, whereas RE projects to CA1 of the dorsal and ventral hippocampus and to the subiculum. SUM and RE fibers to the hippocampus participate in common as well as in separate functions. Both systems would appear to amplify signals from other sources to their respective hippocampal targets. SUM amplifies signals from the entorhinal cortex (EC) to DG, whereas RE may amplify them from CA3 (and EC) to CA1 of the hippocampus. This "amplification" may serve to promote the transfer, encoding, and possibly storage of information from EC to DG and from CA3 and EC to CA1. Regarding their unique actions on the hippocampus, the SUM is a vital part of an ascending brainstem to hippocampal system generating the theta rhythm of the hippocampus, whereas RE importantly routes information from the medial prefrontal cortex to the hippocampus to thereby mediate functions involving both structures. In summary, although, to date, SUM and RE afferents to the hippocampus have not been extensively explored, the SUM and RE exert a profound influence on the hippocampus in processes of learning and memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.