ArticleJournal of biomechanics2015
Dynamic and quasi-static mechanical testing for characterization of the viscoelastic properties of human uterine tissue.
Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Overcoming Mechanical Blindness: Adaptive Surgical Instrument Design for the Heterogeneous Landscape of Uterine Fibroids.Research (Washington, D.C.) · 2026Review
- The Role of Biomechanical Regulation in Physiological and Pathological Pregnancy: From Mechanotransduction to Clinical Implications.International journal of biological sciences · 2026Review
- Time-dependent material properties and composition of the nonhuman primate uterine layers through gestation.Scientific reports · 2025Article
- Time-Dependent Material Properties and Composition of the Nonhuman Primate Uterine Layers Through Gestation.bioRxiv : the preprint server for biology · 2025Article
- Three-Dimensional Printing Strategies for Enhanced Hydrogel Applications.Gels (Basel, Switzerland) · 2024Review
- Comparison of 2D and autostereoscopic 3D visualization during mixed reality simulation.International journal of computer assisted radiology and surgery · 2023Article
- Prevention of Uterine Fibroids: molecular mechanisms and potential clinical application.Journal of endometriosis and uterine disorders · 2023Article
- Regulation of oxytocin-induced calcium transients and gene expression in engineered myometrial tissues by tissue architecture and matrix rigidity.Current research in physiology · 2023Article
- Review
- The Role of Biaxial Loading on Smooth Muscle Contractility in the Nulliparous Murine Cervix.Annals of biomedical engineering · 2021Article
- Tools, techniques, and future opportunities for characterizing the mechanobiology of uterine myometrium.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Layer-specific ultrasound elastography using a multi-layered shear wave dispersion model for assessing the viscoelastic properties.Physics in medicine and biology · 2021Article
- Dynamic Characterization of the Biomechanical Behaviour of Bovine Ovarian Cortical Tissue and Its Short-Term Effect on Ovarian Tissue and Follicles.Materials (Basel, Switzerland) · 2020Article
- A-Kinase Anchoring Protein 13 (AKAP13) Augments Progesterone Signaling in Uterine Fibroid Cells.The Journal of clinical endocrinology and metabolism · 2019Article
- Modeling Ramp-hold Indentation Measurements based on Kelvin-Voigt Fractional Derivative Model.Measurement science & technology · 2018Article
- Automated Compression Device for Viscoelasticity Imaging.IEEE transactions on bio-medical engineering · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ultrasound elastography is envisioned as an optional modality to augment standard ultrasound B-mode imaging and is a promising technique to aid in detecting uterine masses which cause abnormal uterine bleeding in both pre- and post-menopausal women. In order to determine the effectiveness of strain imaging, mechanical testing to establish the elastic contrast between normal uterine tissue and stiffer masses such as leiomyomas (fibroids) and between softer pathologies such as uterine cancer and adenomyosis has to be performed. In this paper, we evaluate the stiffness of normal uterine tissue, leiomyomas, and endometrial cancers using a EnduraTEC ElectroForce (ELF) system. We quantify the viscoelastic characteristics of uterine tissue and associated pathologies globally by using two mechanical testing approaches, namely a dynamic and a quasi-static (ramp testing) approach. For dynamic testing, 21 samples obtained from 18 patients were tested. The testing frequencies were set to 1, 10, 20, and 30 Hz. We also report on stiffness variations with pre-compression from 1% to 6% for testing at 2%, 3%, and 4% strain amplitude. Our results show that human uterine tissue stiffness is both dependent on percent pre-compression and testing frequencies. For ramp testing, 20 samples obtained from 14 patients were used. A constant strain rate of 0.1% was applied and comparable results to dynamic testing were obtained. The mean modulus contrast at 2% amplitude between normal uterine tissue (the background) and leiomyomas was 2.29 and 2.17, and between the background and cancer was 0.47 and 0.39 for dynamic and ramp testing, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.