ArticleBMC infectious diseases2015
Diet patterns and risk of sepsis in community-dwelling adults: a cohort study.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Community-onset sepsis and its public health burden: a systematic review.Systematic reviews · 2016Pooled it
- Adherence to the EAT-Lancet Diet and Risk of Sepsis: A Prospective Cohort Study from the UK Biobank.NPJ science of food · 2026Article
- Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies.Military Medical Research · 2026Article
- "Shaking the ladder" reveals how analytic choices can influence associations in nutrition epidemiology: beef intake and coronary heart disease as a case study.Critical reviews in food science and nutrition · 2026Review
- Nutritional Strategies for the Treatment and Prevention of Sepsis Outside the Intensive Care Unit.Nutrients · 2024Review
- Plant-Based Diets and Risk of Hospitalization with Respiratory Infection: Results from the Atherosclerosis Risk in Communities (ARIC) Study.Nutrients · 2023Article
- Relationship between diet and relative risk of pain in a cross-sectional analysis of the REGARDS longitudinal study.Pain management · 2022Article
- Mediterranean Diet as a Tool to Combat Inflammation and Chronic Diseases. An Overview.Biomedicines · 2020Review
- The Potential for Plant-Based Diets to Promote Health Among Blacks Living in the United States.Nutrients · 2019Review
- Adherence to Mediterranean-style diet and risk of sepsis in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.The British journal of nutrition · 2018Article
- Factors Underlying Racial Disparities in Sepsis Management.Healthcare (Basel, Switzerland) · 2018Review
- Article
- Hotspot Analysis of Sepsis Literature.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Community characteristics and regional variations in sepsis.International journal of epidemiology · 2017Article
- Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis.Critical care medicine · 2017Article
- A prospective study of dietary patterns and cancer mortality among Blacks and Whites in the REGARDS cohort.International journal of cancer · 2016Article
- Dietary patterns are associated with cognitive function in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.Journal of nutritional science · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSepsis is the syndrome of body-wide inflammation triggered by infection and is a major public health problem. Diet plays a vital role in immune health but its association with sepsis in humans is unclear.
methodsWe examined 21,404 participants with available dietary data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a national cohort of 30,239 black and white adults ≥45 years of age living in the US. The primary exposures of interest were five empirically derived diet patterns identified via factor analysis within REGARDS participants: "Convenience" (Chinese and Mexican foods, pasta, pizza, other mixed dishes), "Plant-based" (fruits, vegetables), "Southern" (added fats, fried foods, organ meats, sugar-sweetened beverages), "Sweets/Fats" (sugary foods) and "Alcohol/Salads" (alcohol, green-leafy vegetables, salad dressing). The main outcome of interest was investigator-adjudicated first hospitalized sepsis events.
resultsA total of 970 first sepsis events were observed over ~6 years of follow-up. In unadjusted analyses, greater adherence to Sweets/Fats and Southern patterns was associated with higher cumulative incidence of sepsis, whereas greater adherence to the Plant-based pattern was associated with lower incidence. After adjustment for sociodemographic, lifestyle and clinical factors, greater adherence to the Southern pattern remained associated with higher risk of sepsis (hazard ratio [HR] comparing the fourth to first quartile, HR 1.39, 95 % CI 1.11,1.73). Race modified the association of the Southern diet pattern with sepsis (P interaction = 0.01), with the Southern pattern being associated with modestly higher adjusted risk of sepsis in black as compared to white participants (HR comparing fourth vs. first quartile HR 1.42, 95 % CI 0.75,2.67 vs. 1.21, 95 % CI 0.93,1.57, respectively).
conclusionA Southern pattern of eating was associated with higher risk of sepsis, particularly among black participants. Determining reasons for these findings may help to devise strategies to reduce sepsis risk.
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