ReviewNeuroscience and biobehavioral reviews2015
Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models.
Review in Neuroscience and biobehavioral reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.
- Ibogaine and addiction in the animal model, a systematic review and meta-analysis.Translational psychiatry · 2016Pooled it
- Addiction history moderates the effect of prefrontal 10-Hz transcranial alternating current stimulation on habitual action selection.Journal of neurophysiology · 2021Trial
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- Chemogenetic inhibition of the anterior cingulate cortex increases safe decision-making in aged mice performing the Iowa Gambling Task.Psychopharmacology · 2026Article
- A Selective Cortico-Limbic Network Organizes Behavior During Reward Seeking Under Threat.Journal of neuroscience research · 2026Article
- Chemogenetic modulation of the prelimbic cortex to the nucleus accumbens core pathway reduces cocaine-induced increase of risk preference.Translational psychiatry · 2026Article
- A "personality test" for rats reveals subtle but distinct effects of sex and early life inflammation on brain and behavior.Behavioral neuroscience · 2026Article
- Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks.Molecular psychiatry · 2025Review
- Cognitive flexibility of male rats is increased by augmented punishment in a reversal learning task but ketamine has no detectable long-term effects.Psychopharmacology · 2025Article
- Habenula contributions to negative self-cognitions.Nature communications · 2025Article
- Developmental Shifts in Amygdala Function.Current topics in behavioral neurosciences · 2025Review
- Effects of maternal separation on punishment-driven risky decision making in adolescence and adulthood.Neurobiology of learning and memory · 2025Article
- Cholinergic regulation of decision making under risk of punishment.Neurobiology of learning and memory · 2025Article
- Neural mechanisms of maladaptive risk decision-making across psychiatric disorders.Frontiers in behavioral neuroscience · 2025Review
- Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Dissociable Roles of the mPFC-to-VTA Pathway in the Control of Impulsive Action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats.The international journal of neuropsychopharmacology · 2024Article
- Effects of adolescent intermittent ethanol exposure on cortical perineuronal net and parvalbumin expression in adulthood mediate behavioral inflexibility.Alcohol, clinical & experimental research · 2024Article
- In a circuit necessary for cognition and emotional affect, Alzheimer's-like pathology associates with neuroinflammation, cognitive and motivational deficits in the young adult TgF344-AD rat.Brain, behavior, & immunity - health · 2024Article
- Acute stress differentially alters reward-related decision making and inhibitory control under threat of punishment.Neurobiology of stress · 2024Review
- AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula.Communications biology · 2024Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
Over the past 20 years there has been a growing interest in the neural underpinnings of cost/benefit decision-making. Recent studies with animal models have made considerable advances in our understanding of how different prefrontal, striatal, limbic and monoaminergic circuits interact to promote efficient risk/reward decision-making, and how dysfunction in these circuits underlies aberrant decision-making observed in numerous psychiatric disorders. This review will highlight recent findings from studies exploring these questions using a variety of behavioral assays, as well as molecular, pharmacological, neurophysiological, and translational approaches. We begin with a discussion of how neural systems related to decision subcomponents may interact to generate more complex decisions involving risk and uncertainty. This is followed by an overview of interactions between prefrontal-amygdala-dopamine and habenular circuits in regulating choice between certain and uncertain rewards and how different modes of dopamine transmission may contribute to these processes. These data will be compared with results from other studies investigating the contribution of some of these systems to guiding decision-making related to rewards vs. punishment. Lastly, we provide a brief summary of impairments in risk-related decision-making associated with psychiatric disorders, highlighting recent translational studies in laboratory animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.