ArticleBiochemistry. Biokhimiia2015
Ancient Systems of Sodium/Potassium Homeostasis as Predecessors of Membrane Bioenergetics.
Article in Biochemistry. Biokhimiia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 86 citations in OpenAlex.
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- Temporal control of Staphylococcus aureus intracellular pH by sodium and potassium.FEMS microbiology letters · 2024Article
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- Potassium at the Origins of Life: Did Biology Emerge from Biotite in Micaceous Clay?Life (Basel, Switzerland) · 2022Article
- Significance of two transmembrane ion gradients for human erythrocyte volume stabilization.PloS one · 2022Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Cell cytoplasm of archaea, bacteria, and eukaryotes contains substantially more potassium than sodium, and potassium cations are specifically required for many key cellular processes, including protein synthesis. This distinct ionic composition and requirements have been attributed to the emergence of the first cells in potassium-rich habitats. Different, albeit complementary, scenarios have been proposed for the primordial potassium-rich environments based on experimental data and theoretical considerations. Specifically, building on the observation that potassium prevails over sodium in the vapor of inland geothermal systems, we have argued that the first cells could emerge in the pools and puddles at the periphery of primordial anoxic geothermal fields, where the elementary composition of the condensed vapor would resemble the internal milieu of modern cells. Marine and freshwater environments generally contain more sodium than potassium. Therefore, to invade such environments, while maintaining excess of potassium over sodium in the cytoplasm, primordial cells needed means to extrude sodium ions. The foray into new, sodium-rich habitats was the likely driving force behind the evolution of diverse redox-, light-, chemically-, or osmotically-dependent sodium export pumps and the increase of membrane tightness. Here we present a scenario that details how the interplay between several, initially independent sodium pumps might have triggered the evolution of sodium-dependent membrane bioenergetics, followed by the separate emergence of the proton-dependent bioenergetics in archaea and bacteria. We also discuss the development of systems that utilize the sodium/potassium gradient across the cell membranes.
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