ReviewCurrent hypertension reports2015
Cardiovascular Autonomic Dysfunction in Chronic Kidney Disease: a Comprehensive Review.
Review in Current hypertension reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- A systematic review and meta-analysis investigating the impact of exercise interventions on heart rate variability in hemodialysis patients.Scientific reports · 2024Pooled it
- Pre-existing anxiety and mood disorders and multisystem outcomes in young adults with chronic kidney disease.Clinical kidney journal · 2026Article
- Phenotype-Specific Heterogeneity in Acute Kidney Injury, Dialysis, and Mortality Among Hospitalized Patients with Chronic Kidney Disease: A National Retrospective Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Article
- Autonomic-vascular dysregulation in CKD-associated hypertension: a narrative review with evidence hierarchy.Frontiers in neuroscience · 2026Review
- Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The association between systolic and diastolic dysfunction and autonomic nervous system function in children receiving chronic hemodialysis.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Association between heart rate fragmentation and kidney function decline in MESA: evidence consistent with parasympathetic degradation.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Article
- Review
- 10 tips on how to manage severe arrhythmia in haemodialysis patients.Clinical kidney journal · 2025Review
- Noninvasive assessment of temporal dynamics in sympathetic and parasympathetic baroreflex responses.Physiological measurement · 2025Article
- Article
- Assessment of cardiac autonomic dysfunction in patients with chronic kidney disease using heart rate variability.Bioinformation · 2025Article
- Cardiac Autonomic Modulation in Domestic Cats with Obstructive Lower Urinary Tract Disease.Animals : an open access journal from MDPI · 2024Article
- Cardiovascular autonomic neuropathy in chronic kidney disease: a study of kidney biopsy cases.BMC nephrology · 2024Article
- Noninvasive Assessment of Temporal Dynamics in Sympathetic and Parasympathetic Baroreflex Responses.bioRxiv : the preprint server for biology · 2024Article
- Comparison of Cardiac Autonomic Innervation in Postmortem Tissue from Individuals with Kidney Failure and Preserved Kidney Function.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Impact of sympathetic hyperactivity induced by brain microglial activation on organ damage in sepsis with chronic kidney disease.Journal of intensive care · 2024Article
- A cross-sectional study on the impact of hemodialysis duration on retinal nerve fiber layer thinning in hemodialysis patients.Scientific reports · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular autonomic dysfunction is a major complication of chronic kidney disease (CKD), likely contributing to the high incidence of cardiovascular mortality in this patient population. In addition to adrenergic overdrive in affected individuals, clinical and experimental evidence now strongly indicates the presence of impaired reflex control of both sympathetic and parasympathetic outflow to the heart and vasculature. Although the principal underlying mechanisms are not completely understood, potential involvements of altered baroreceptor, cardiopulmonary, and chemoreceptor reflex function, along with factors including but not limited to increased renin-angiotensin-aldosterone system activity, activation of the renal afferents and cardiovascular structural remodeling have been suggested. This review therefore analyzes potential mechanisms underpinning autonomic imbalance in CKD, covers results accumulated thus far on cardiovascular autonomic function studies in clinical and experimental renal failure, discusses the role of current interventional and therapeutic strategies in ameliorating autonomic deficits associated with chronic renal dysfunction, and identifies gaps in our knowledge of neural mechanisms driving cardiovascular disease in CKD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.