ArticleAtherosclerosis2015
The relationship between carotid intima-media thickness and carotid plaque in the Northern Manhattan Study.
Article in Atherosclerosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05951894 (Flow-mediated Arterial Dilatation, Hypertension, Endothelin-1), which is not on this map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Flow-mediated Arterial Dilatation, Hypertension, Endothelin-1 (ET-1) and Soluble Intercellular Adhesion Molecule (sICAM-1) in Obese Adolescents
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effect of Oral Hypoglycaemic Agents on Carotid Artery Intima-Media Thickness in Patients With Cardiovascular Disease and/or Diabetes-A Systematic Review.Endocrinology, diabetes & metabolism · 2025Pooled it
- Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies.Journal of the American Heart Association · 2023Pooled it
- Carotid intima-media thickness predicts carotid plaque development: Meta-analysis of seven studies involving 9341 participants.European journal of clinical investigation · 2020Pooled it
- Association of metabolic syndrome with carotid thickening and plaque in the general population: A meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2018Pooled it
- Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis.Scientific reports · 2018Trial
- Association Between Inflammatory Biomarkers And Carotid Ultrasound Parameters In The Northern Manhattan Stroke Study.Translational stroke research · 2026Article
- Diagnostic Performance of Carotid Contrast-Enhanced Ultrasound for Identifying Functionally Significant Coronary Artery Stenosis Assessed by Quantitative Flow Ratio: A Preliminary Prospective Study.Journal of cardiovascular development and disease · 2026Article
- Association between Cardiovascular Risk Factors and Carotid Plaques in a Population-Based Study - The SHIP-Brazil Study.Arquivos brasileiros de cardiologia · 2025Article
- The association of carotid plaque burden and composition and the coronary artery calcium score in intermediate cardiovascular risk patients.The international journal of cardiovascular imaging · 2024Article
- Value of carotid intima thickness in assessing advanced carotid plaque vulnerability: a study based on carotid artery ultrasonography and carotid plaque histology.Quantitative imaging in medicine and surgery · 2024Article
- Extracranial carotid artery atherosclerotic plaque and APOE polymorphisms: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Article
- Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospital.Chinese journal of integrative medicine · 2022Article
- Systemic Arterial Correlates of Cervical Carotid Artery Tortuosity : The Northern Manhattan Study.Clinical neuroradiology · 2022Article
- Tree nut consumption and prevalence of carotid artery plaques: The National Heart, Lung, and Blood Institute Family Heart Study.European journal of nutrition · 2022Article
- Association Between Retinal Microvascular Metrics Using Optical Coherence Tomography Angiography and Carotid Artery Stenosis in a Chinese Cohort.Frontiers in physiology · 2022Article
- Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals.Clinics (Sao Paulo, Brazil) · 2022Article
- Clinical Significance of Carotid Intima-Media Complex and Carotid Plaque Assessment by Ultrasound for the Prediction of Adverse Cardiovascular Events in Primary and Secondary Care Patients.Journal of clinical medicine · 2021Review
- Clusters of Cardiometabolic Risk Factors and Their Association with Atherosclerosis and Chronic Inflammation among Adults and Elderly in Florianópolis, Southern Brazil.Arquivos brasileiros de cardiologia · 2021Article
- Cardiovascular/stroke risk predictive calculators: a comparison between statistical and machine learning models.Cardiovascular diagnosis and therapy · 2020Article
- The coronary artery calcium score is linked to plasma cholesterol synthesis and absorption markers: Brazilian Longitudinal Study of Adult Health.Bioscience reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
objectiveCarotid intima-media thickness (cIMT) and carotid plaque (CP) are proposed biomarkers of subclinical atherosclerosis associated with stroke risk. Whether cIMT and CP are distinct phenotypes or single traits at different stages of atherosclerotic development is unclear. We explored the relationship between these markers in the population-based Northern Manhattan Study.
methodsWe used high-resolution ultrasound and validated imaging protocols to study the cross-sectional (N = 1788 stroke-free participants) and prospective relationship (N = 768 with follow-up scan; mean years between examinations = 3.5) between CP and cIMT measured in plaque-free areas.
resultsThe mean age was 66 ± 9 (40% male, 19% black, 17% white, 61% Hispanic). The mean baseline cIMT was 0.92 ± 0.09 mm, 0.94 ± 0.09 mm among the 58% with prevalent plaque, 0.90 ± 0.08 mm among the 42% without prevalent plaque (p < 0.0001). Each 0.1 mm increase in baseline cIMT was associated with a 1.72-fold increased odds of plaque presence (95%CI = 1.50-1.97), increased plaque thickness (effect on the median = 0.46 mm, p < 0.0001), and increased plaque area (effect on the median = 3.45 mm(2), p < 0.0001), adjusting for demographics and vascular risk factors. Elevated baseline cIMT was associated with an increased risk of new plaque in any location at follow-up, but after adjusting for demographics and vascular risk factors this association was no longer present. No association was observed in carotid segment-specific analyses.
conclusionIncreased cIMT was associated with baseline prevalent plaque but did not predict incident plaque independent of other vascular risk factors. This finding suggests that increased cIMT is not an independent predictor of plaque development although these atherosclerotic phenotypes often coexist and share some common vascular determinants.
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