Evidence map›Paper›PMID 26071438›Full record

ArticleBMJ case reports2015

GeneXpert MTB/RIF assay as initial test for diagnosis of tuberculous meningitis.

Poojan Shrestha, Buddhi Paudyal, Buddha Basnyat

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Poojan ShresthaClinical Research Unit, Oxford University, Patan Hospital, Kathmandu, Nepal.
Buddhi PaudyalDepartment of Internal Medicine, Patan Academy of Health Sciences, Kathmandu, Nepal.
Buddha BasnyatClinical Research Unit, Oxford University, Kathmandu, Nepal.
Kathmandu University · NPPatan Academy of Health Sciences · NPPatan Hospital · NP

Funding

Wellcome Trust 089276
6 · The paper itself

Abstract

Tuberculous meningitis (TBM) remains the most dangerous form of tuberculosis with high mortality and potential complications. The prompt diagnosis and treatment of this condition remains a key for better prognosis. A 39-year-old woman presented with severe headache, fever, nausea and vomiting, with a history of headache for a month. On examination, confusion, neck rigidity, ptosis and upward plantar reflexes were present. After 7 days of empiric treatment without resolution of her symptoms, she had another spinal tap performed. The diagnosis of TBM was performed by the GeneXpert MTB/RIF assay from her cerebrospinal fluid (CSF). Antitubercular chemotherapy was started. The patient subsequently improved. Where available, the GeneXpert assay should be used immediately in CSF samples of patients suspected of TBM as an adjunct to clinical algorithms to increase the chance of a prompt diagnosis and treatment.

Indexed as

Molecular Diagnostic TechniquesAdultAntitubercular AgentsFemaleFeverHeadache DisordersHumansMicrobial Sensitivity TestsMycobacterium tuberculosisPrognosisSpinal PunctureTreatment OutcomeTuberculosis, MeningealAntitubercular Agents

Identifiers

PMID26071438
PMCPMC4480084
OpenAlexW2318270533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.