ArticleExperimental parasitology2015
IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia.
Article in Experimental parasitology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed, 88 citations in OpenAlex.
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- Dynamics of Th17-Associated Cytokine Responses During the Intestinal-Dwelling Protozoan Parasite Giardia duodenalis Infection in Mice and Human Subjects.Acta parasitologica · 2026Article
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- Interactions between bacterial microbiota and protozoan parasites: an intimate relationship.Archives of microbiology · 2026Review
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- Effect of inoculation dose on infection kinetics and immune responses to Giardia.Scientific reports · 2025Article
- Unravelling the cellular sources and location of IL-17A production during a Giardia infection.Scientific reports · 2025Article
- Giardia-induced Type 2 mucosal immunity attenuates intestinal inflammation caused by co-infection or colitis in mice.Nature microbiology · 2025Article
- High efficacy of camphene and metronidazole combination therapy againstParasite epidemiology and control · 2025Article
- Immune-iron homeostasis deciphers resistance divergence toFrontiers in microbiology · 2025Article
- The Influence of the ProtozoanInternational journal of molecular sciences · 2024Review
- Mucosal vaccination in a murine gnotobiotic model ofInfection and immunity · 2024Article
- Article
- Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Asthma-associated bacterial infections: Are they protective or deleterious?The journal of allergy and clinical immunology. Global · 2023Review
- Microbial Components and Effector Molecules in T Helper Cell Differentiation and Function.Immune network · 2023Review
- DietaryPathogens (Basel, Switzerland) · 2023Article
5 more citing papers are in PubMed but not listed here.
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12 authors at 3 institutions in 1 country.
Funding
Abstract
Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide. It colonizes the lumen and epithelial surface of the small intestine, but does not invade the mucosa. Acute infection causes only minimal mucosal inflammation. Effective immune defenses exist, yet their identity and mechanisms remain incompletely understood. Interleukin (IL)-17A has emerged as an important cytokine involved in inflammation and antimicrobial defense against bacterial pathogens at mucosal surfaces. In this study, we demonstrate that IL-17A has a crucial function in host defense against Giardia infection. Using murine infection models with G. muris and G. lamblia, we observed marked and selective induction of intestinal IL-17A with peak expression after 2 weeks. Th17 cells in the lamina propria and innate immune cells in the epithelial compartment of the small intestine were responsible for the IL-17A response. Experiments in gene-targeted mice revealed that the cytokine, and its cognate receptor IL-17RA, were required for eradication of the parasite. The actions of the cytokine were mediated by hematopoietic cells, and were required for the transport of IgA into the intestinal lumen, since IL-17A deficiency led to marked reduction of fecal IgA levels, as well as for increased intestinal expression of several other potential effectors, including β-defensin 1 and resistin-like molecule β. In contrast, intestinal hypermotility, another major antigiardial defense mechanism, was not impacted by IL-17A loss. Taken together, these findings demonstrate that IL-17A and IL-17 receptor signaling are essential for intestinal defense against the important lumen-dwelling intestinal parasite Giardia.
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