Evidence map›Paper›PMID 26070843›Full record

ArticleDevelopmental cognitive neuroscience2015

Does incentive-elicited nucleus accumbens activation differ by substance of abuse? An examination with adolescents.

Hollis C Karoly, Angela D Bryan, Barbara J Weiland, Andrew Mayer, Andrew Dodd, Sarah W Feldstein Ewing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cognitive neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Nonacute effects of cannabis use on motivation and reward sensitivity in humans: A systematic review.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2018
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  14. Neural responses to reward anticipation and feedback in adult and adolescent cannabis users and controls.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hollis C KarolyUniversity of Colorado, Boulder, Department of Psychology and Neuroscience, 345 UCB, Boulder, CO 80309, USA. Electronic address: hollis.karoly@colorado.edu.
Angela D BryanUniversity of Colorado, Boulder, Department of Psychology and Neuroscience, 345 UCB, Boulder, CO 80309, USA.
Barbara J WeilandUniversity of Colorado, Boulder, Department of Psychology and Neuroscience, 345 UCB, Boulder, CO 80309, USA.
Andrew MayerThe Mind Research Network/LBERI, Albuquerque, NM 87106, USA; Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA; Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
Andrew DoddThe Mind Research Network/LBERI, Albuquerque, NM 87106, USA.
Sarah W Feldstein EwingDepartment of Psychiatry, Oregon Health & Science University, Portland, OR 97239, USA.

Funding

Adolescent decision making and HIV risk avoidance: Neurocognitive factorsR01NR013332 · NINR · UNIVERSITY OF NEW MEXICO · PI BRYAN, ANGELA, FELDSTEIN EWING, SARAH W. · 2011 to 2015
$2.7M
NINR NIH HHS 1R01NR013332-01NINR NIH HHS R01 NR013332
6 · The paper itself

Abstract

Numerous questions surround the nature of reward processing in the developing adolescent brain, particularly in regard to polysubstance use. We therefore sought to examine incentive-elicited brain activation in the context of three common substances of abuse (cannabis, tobacco, and alcohol). Due to the role of the nucleus accumbens (NAcc) in incentive processing, we compared activation in this region during anticipation of reward and loss using a monetary incentive delay (MID) task. Adolescents (ages 14-18; 66% male) were matched on age, gender, and frequency of use of any common substances within six distinct groups: cannabis-only (n=14), tobacco-only (n=34), alcohol-only (n=12), cannabis+tobacco (n=17), cannabis+tobacco+alcohol (n=17), and non-using controls (n=38). All groups showed comparable behavioral performance on the MID task. The tobacco-only group showed decreased bilateral nucleus accumbens (NAcc) activation during reward anticipation as compared to the alcohol-only group, the control group, and both polysubstance groups. Interestingly, no differences emerged between the cannabis-only group and any of the other groups. Results from this study suggest that youth who tend toward single-substance tobacco use may possess behavioral and/or neurobiological characteristics that differentiate them from both their substance-using and non-substance-using peers.

Indexed as

RewardAdolescentAdolescent BehaviorAlcoholismAnticipation, PsychologicalDelay DiscountingDrug InteractionsExploratory BehaviorFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMarijuana AbuseNucleus AccumbensSocioeconomic FactorsAdolescentCannabisfMRIMonetary incentive delayTobacco

Identifiers

PMID26070843
PMCPMC4657439

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.