ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2015
Interaction between parental psychosis and early motor development and the risk of schizophrenia in a general population birth cohort.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Systematic Review: Antipsychotic Medication in Pregnancy and Neurodevelopmental Outcomes in Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- MESS to live with schizophrenic parental history: A systematic review of developmental checkpoints.PloS one · 2025Pooled it
- Delineating the Transmission of Subthreshold Psychosis Symptoms Across Generations: The Philadelphia Family Neurodevelopmental Cohort.Schizophrenia bulletin · 2025Article
- A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms.Schizophrenia bulletin · 2025Article
- Article
- Connecting Neurobiological Features with Interregional Dysconnectivity in Social-Cognitive Impairments of Schizophrenia.International journal of molecular sciences · 2023Review
- Sensorimotor and Activity Psychosis-Risk (SMAP-R) Scale: An Exploration of Scale Structure With Replication and Validation.Schizophrenia bulletin · 2021Article
- Robust data-driven identification of risk factors and their interactions: A simulation and a study of parental and demographic risk factors for schizophrenia.International journal of methods in psychiatric research · 2020Article
- Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample.Social psychiatry and psychiatric epidemiology · 2020Article
- Epidemiology of schizophrenia and its management over 8-years period using real-world data in Spain.BMC psychiatry · 2020Article
- Prediction, Psychosis, and the Cerebellum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Association between developmental milestones and age of schizophrenia onset: Results from the Northern Finland Birth Cohort 1966.Schizophrenia research · 2019Article
- Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966.Schizophrenia bulletin · 2018Article
- Motor System Pathology in Psychosis.Current psychiatry reports · 2017Review
- Altered growth trajectory of head circumference during infancy and schizophrenia in a National Birth Cohort.Schizophrenia research · 2017Article
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11 authors at 5 institutions in 3 countries.
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Abstract
backgroundDelayed motor development in infancy and family history of psychosis are both associated with increased risk of schizophrenia, but their interaction is largely unstudied.
aimTo investigate the association of the age of achieving motor milestones and parental psychosis and their interaction in respect to risk of schizophrenia.
methodsWe used data from the general population-based prospective Northern Finland Birth Cohort 1966 (n=10,283). Developmental information of the cohort members was gathered during regular visits to Finnish child welfare clinics. Several registers were used to determine the diagnosis of schizophrenia among the cohort members and psychosis among the parents. Altogether 152 (1.5%) individuals had schizophrenia by the age of 46 years, with 23 (15.1%) of them having a parent with psychosis. Cox regression analysis was used in analyses.
resultsParental psychosis was associated (P<0.05) with later achievement of holding the head up, grabbing an object, and walking without support. In the parental psychosis group, the risk for schizophrenia was increased if holding the head up (hazard ratio [HR]: 2.46; degrees of freedom [df]=1; 95% confidence interval [95% CI]: 1.07-5.66) and touching the thumb with the index finger (HR: 1.84; df=1; 95% CI: 1.11-3.06) was later. In the group without parental psychosis, a delay in the following milestones increased the risk of schizophrenia: standing without support and walking without support. Parental psychosis had an interaction with delayed touching thumb with index finger (HR: 1.87; df=1; 95% CI: 1.08-3.25) when risk of schizophrenia was investigated.
conclusionsParental psychosis was associated with achieving motor milestones later in infancy, particularly the milestones that appear early in a child's life. Parental psychosis and touching the thumb with the index finger had a significant interaction on risk of schizophrenia. Genetic risk for psychosis may interact with delayed development to raise future risk of schizophrenia, or delayed development may be a marker of other risk processes that interact with genetic liability to cause later schizophrenia.
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