ArticleApplied and environmental microbiology2015
Sharply Tuned pH Response of Genetic Competence Regulation in Streptococcus mutans: a Microfluidic Study of the Environmental Sensitivity of comX.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Competence shut-off by intracellular pheromone degradation in salivarius streptococci.PLoS genetics · 2022Article
- The transcription regulator BrsR serves as a network hub of natural competence protein-protein interactions inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans.Nature microbiology · 2021Article
- Direct interactions with commensal streptococci modify intercellular communication behaviors of Streptococcus mutans.The ISME journal · 2021Article
- Environmental Triggers ofFrontiers in microbiology · 2020Article
- Acetate and Potassium Modulate the Stationary-Phase Activation ofFrontiers in microbiology · 2020Article
- Novel Probiotic Mechanisms of the Oral BacteriumApplied and environmental microbiology · 2019Article
- Carbohydrate and PepO control bimodality in competence development by Streptococcus mutans.Molecular microbiology · 2019Article
- Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway.Nature communications · 2019Article
- Regulation of cid and lrg expression by CcpA in Streptococcus mutans.Microbiology (Reading, England) · 2019Article
- Expanding the Vocabulary of Peptide Signals inFrontiers in cellular and infection microbiology · 2019Review
- Threshold regulation and stochasticity from the MecA/ClpCP proteolytic system in Streptococcus mutans competence.Molecular microbiology · 2018Article
- Intracellular Signaling by themSphere · 2018Article
- Competence inhibition by the XrpA peptide encoded within the comX gene of Streptococcus mutans.Molecular microbiology · 2018Article
- Genome-Wide Screens Reveal New Gene Products That Influence Genetic Competence in Streptococcus mutans.Journal of bacteriology · 2018Article
- Oxidative Stressors Modify the Response of Streptococcus mutans to Its Competence Signal Peptides.Applied and environmental microbiology · 2017Article
- Intercellular Communication via theJournal of bacteriology · 2017Article
- Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence.Nature communications · 2017Article
- Origins of heterogeneity in Streptococcus mutans competence: interpreting an environment-sensitive signaling pathway.Physical biology · 2017Article
- RNA-Seq Reveals Enhanced Sugar Metabolism inFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Genetic competence in Streptococcus mutans is a transient state that is regulated in response to multiple environmental inputs. These include extracellular pH and the concentrations of two secreted peptides, designated CSP (competence-stimulating peptide) and XIP (comX-inducing peptide). The role of environmental cues in regulating competence can be difficult to disentangle from the effects of the organism's physiological state and its chemical modification of its environment. We used microfluidics to control the extracellular environment and study the activation of the key competence gene comX. We find that the comX promoter (PcomX) responds to XIP or CSP only when the extracellular pH lies within a narrow window, about 1 pH unit wide, near pH 7. Within this pH range, CSP elicits a strong PcomX response from a subpopulation of cells, whereas outside this range the proportion of cells expressing comX declines sharply. Likewise, PcomX is most sensitive to XIP only within a narrow pH window. While previous work suggested that comX may become refractory to CSP or XIP stimulus as cells exit early exponential phase, our microfluidic data show that extracellular pH dominates in determining sensitivity to XIP and CSP. The data are most consistent with an effect of pH on the ComR/ComS system, which has direct control over transcription of comX in S. mutans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.