ArticleApplied and environmental microbiology2015
Diversity of O Antigens within the Genus Cronobacter: from Disorder to Order.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
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- Occurrence, molecular characterization and antibiotic resistance ofCurrent research in food science · 2023Article
- Cronobacter sakazakii Cue for the Attraction and Its Impact on the Immunity of Caenorhabditis elegans.Infection and immunity · 2022Article
- Membrane Proteins and Proteomics of Cronobacter sakazakii Cells: Reliable Method for Identification and Subcellular Localization.Applied and environmental microbiology · 2022Article
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- Application of MALDI-TOF mass spectrometry, and DNA sequencing-based SLST and MLST analysis for the identification of Cronobacter spp. isolated from environmental surveillance samples.Archives of microbiology · 2021Article
- Multicenter Study of Cronobacter sakazakii Infections in Humans, Europe, 2017.Emerging infectious diseases · 2019Article
- Prevalence, Antibiotic Susceptibility, and Molecular Characterization ofFrontiers in microbiology · 2019Article
- Prevalence and Molecular and Antimicrobial Characteristics ofFrontiers in microbiology · 2018Article
- Open-access bacterial population genomics: BIGSdb software, the PubMLST.org website and their applications.Wellcome open research · 2018Article
- Prevalence, Molecular Characterization, and Antibiotic Susceptibility ofFrontiers in microbiology · 2017Article
- DNA-Sequence Based Typing of theFrontiers in microbiology · 2017Article
- Multiplexed Lateral Flow Test for Detection and Differentiation ofFrontiers in microbiology · 2017Article
- Simultaneous Rapid Detection and Serotyping of Cronobacter sakazakii Serotypes O1, O2, and O3 by Using Specific Monoclonal Antibodies.Applied and environmental microbiology · 2016Article
- Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Cronobacter species are Gram-negative opportunistic pathogens that can cause serious infections in neonates. The lipopolysaccharides (LPSs) that form part of the outer membrane of such bacteria are possibly related to the virulence of particular bacterial strains. However, currently there is no clear overview of O-antigen diversity within the various Cronobacter strains and links with virulence. In this study, we tested a total of 82 strains, covering each of the Cronobacter species. The nucleotide variability of the O-antigen gene cluster was determined by restriction fragment length polymorphism (RFLP) analysis. As a result, the 82 strains were distributed into 11 previously published serotypes and 6 new serotypes, each defined by its characteristic restriction profile. These new serotypes were confirmed using genomic analysis of strains available in public databases: GenBank and PubMLST Cronobacter. Laboratory strains were then tested using the current serotype-specific PCR probes. The results show that the current PCR probes did not always correspond to genomic O-antigen gene cluster variation. In addition, we analyzed the LPS phenotype of the reference strains of all distinguishable serotypes. The identified serotypes were compared with data from the literature and the MLST database (www.pubmlst.org/cronobacter/). Based on the findings, we systematically classified a total of 24 serotypes for the Cronobacter genus. Moreover, we evaluated the clinical history of these strains and show that Cronobacter sakazakii O2, O1, and O4, C. turicensis O1, and C. malonaticus O2 serotypes are particularly predominant in clinical cases.
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