Evidence map›Paper›PMID 26070567›Full record

ArticleThe Journal of biological chemistry2015

Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis.

Chadia L Robertson, Jyoti Srivastava, Ayesha Siddiq, Rachel Gredler, Luni Emdad, Devaraja Rajasekaran, Maaged Akiel, Xue-Ning Shen, Frank Corwin, Gobalakrishnan Sundaresan and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Chadia L RobertsonDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298; Departments of Biochemistry, Virginia Commonwealth University, Richmond, Virginia 23298.
Jyoti SrivastavaDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298.
Ayesha SiddiqDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298.
Rachel GredlerDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298.
Luni EmdadDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298.
Devaraja RajasekaranDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298.
Maaged AkielDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298.
Xue-Ning ShenDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298.
Frank CorwinDepartments of Radiology, Virginia Commonwealth University, Richmond, Virginia 23298.
Gobalakrishnan SundaresanDepartments of Radiology, Virginia Commonwealth University, Richmond, Virginia 23298.
Jamal ZweitDepartments of Radiology, Virginia Commonwealth University, Richmond, Virginia 23298.
Colleen CronigerDepartment of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106.
Xiaoli GaoInstitutional Mass Spectrometry Laboratory, University of Texas Health Science Center, San Antonio, Texas 78229.
Shobha GhoshDepartments of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298.
Philip B HylemonDepartments of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia 23298.
Mark A SublerDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298.
Jolene J WindleDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298; Departments of VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298.
Paul B FisherDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298; Departments of VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, Virginia 23298.
Devanand SarkarDepartments of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia 23298; Departments of VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, Virginia 23298. Electronic address: dsarkar@vcu.edu.
Virginia Commonwealth University · USCase Western Reserve University · USThe University of Texas Health Science Center at San Antonio · US

Funding

Training Grant in Digestive Diseases and Liver DiseasesT32DK007150 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SANYAL, ARUN J · 1986 to 2017
$4.2M
Analysis of a novel regulator of hepatocellular carcinomaR01CA138540 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SARKAR, DEVANAND · 2010 to 2014
$1.6M
AEG-1: Novel Gene Involved in Malignant GliomaR01CA134721 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI FISHER, PAUL B · 2009 to 2013
$1.5M
A novel mediator of obesity associated hepatocellular carcinoma (HCC)R21CA183954 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SARKAR, DEVANAND · 2014 to 2015
$365k
NCI NIH HHS R01 CA134721NCI NIH HHS R01 CA138540NCI NIH HHS R21 CA183954NIDDK NIH HHS T32 DK007150
6 · The paper itself

Abstract

Astrocyte elevated gene-1 (AEG-1), also known as MTDH (metadherin) or LYRIC, is an established oncogene. However, the physiological function of AEG-1 is not known. To address this question, we generated an AEG-1 knock-out mouse (AEG-1KO) and characterized it. Although AEG-1KO mice were viable and fertile, they were significantly leaner with prominently less body fat and lived significantly longer compared with wild type (WT). When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1KO mice did not gain weight at all. This phenotype of AEG-1KO mice is due to decreased fat absorption from the intestines, not because of decreased fat synthesis or increased fat consumption. AEG-1 interacts with retinoid X receptor (RXR) and inhibits RXR function. In enterocytes of AEG-1KO mice, we observed increased activity of RXR heterodimer partners, liver X receptor and peroxisome proliferator-activated receptor-α, key inhibitors of intestinal fat absorption. Inhibition of fat absorption in AEG-1KO mice was further augmented when fed an HFD providing ligands to liver X receptor and peroxisome proliferator-activated receptor-α. Our studies reveal a novel role of AEG-1 in regulating nuclear receptors controlling lipid metabolism. AEG-1 may significantly modulate the effects of HFD and thereby function as a unique determinant of obesity.

Indexed as

Lipid MetabolismWeight GainAdipose TissueAnimalsHomeostasisIntestinal MucosaLiverLiver X ReceptorsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutObesityOrphan Nuclear ReceptorsPeroxisome Proliferator-Activated ReceptorsLiver X ReceptorsMembrane ProteinsMtdh protein, mouseOrphan Nuclear ReceptorsPeroxisome Proliferator-Activated ReceptorsRetinoid X ReceptorsRNA-Binding Proteinsgene regulationintestinelipidliver metabolismperoxisome proliferator-activated receptor (PPAR)

Identifiers

PMID26070567
PMCPMC4505065
OpenAlexW1859700751

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.