Evidence map›Paper›PMID 26070517›Full record

SynthesisClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016

Effects of non-invasive brain stimulation on post-stroke dysphagia: A systematic review and meta-analysis of randomized controlled trials.

Jessica M Pisegna, Asako Kaneoka, William G Pearson, Sandeep Kumar, Susan E Langmore

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 15 pooled it
31.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 15 syntheses or guidelines pooled it, 161 citations in OpenAlex.

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  5. Effect of non-invasive brain stimulation on conscious disorder in patients after brain injury: a network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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  15. Swallowing therapy for dysphagia in acute and subacute stroke.The Cochrane database of systematic reviews · 2018
    Pooled it
  16. Unilateral contralesional versus bilateral repetitive transcranial magnetic stimulation for patients with post stroke dysphagia: a randomized controlled study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jessica M PisegnaBoston University Medical Center, FGH Building 820 Harrison Ave., Boston, MA 02118, United States; Boston University, Sargent College, 635 Commonwealth Ave., Boston, MA 02215, United States. Electronic address: jpisegna@bu.edu.
Asako KaneokaBoston University Medical Center, FGH Building 820 Harrison Ave., Boston, MA 02118, United States; Boston University, Sargent College, 635 Commonwealth Ave., Boston, MA 02215, United States. Electronic address: kaneoka@bu.edu.
William G PearsonGeorgia Regents University, 1120 15th St., Augusta, GA 30912, United States. Electronic address: wpearson@gru.edu.
Sandeep KumarBeth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, United States. Electronic address: skumar@bidmc.harvard.edu.
Susan E LangmoreBoston University Medical Center, FGH Building 820 Harrison Ave., Boston, MA 02118, United States; Boston University, Sargent College, 635 Commonwealth Ave., Boston, MA 02215, United States. Electronic address: langmore@bu.edu.
Boston University · USAugusta University · USBeth Israel Deaconess Medical Center · US

Funding

Non-invasive brain stimulation for swallowing recovery after a dysphagic strokeR01DC012584 · NIDCD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KUMAR, SANDEEP · 2013 to 2017
$2.9M
NIDCD NIH HHS 1R01DC012584-01A1NIDCD NIH HHS R01 DC012584NIDCD NIH HHS R01DC012584
6 · The paper itself

Abstract

objectiveThe primary aim of this review is to evaluate the effects of non-invasive brain stimulation on post-stroke dysphagia.

methodsThirteen databases were systematically searched through July 2014. Studies had to meet pre-specified inclusion and exclusion criteria. Each study's methodological quality was examined. Effect sizes were calculated from extracted data and combined for an overall summary statistic.

resultsEight randomized controlled trials were included. These trials revealed a significant, moderate pooled effect size (0.55; 95% CI=0.17, 0.93; p=0.004). Studies stimulating the affected hemisphere had a combined effect size of 0.46 (95% CI=-0.18, 1.11; p=0.16); studies stimulating the unaffected hemisphere had a combined effect size of 0.65 (95% CI=0.14, 1.16; p=0.01). At long-term follow up, three studies demonstrated a large but non-significant pooled effect size (0.81, p=0.11).

conclusionsThis review found evidence for the efficacy of non-invasive brain stimulation on post-stroke dysphagia. A significant effect size resulted when stimulating the unaffected rather than the affected hemisphere. This finding is in agreement with previous studies implicating the plasticity of cortical neurons in the unaffected hemisphere. SIGNIFICANCE: Non-invasive brain stimulation appears to assist cortical reorganization in post-stroke dysphagia but emerging factors highlight the need for more data.

Indexed as

Deglutition DisordersElectric Stimulation TherapyHumansRandomized Controlled Trials as TopicStrokeTranscranial Magnetic StimulationTreatment OutcomeDysphagiaNon-invasive brain stimulationPost-stroke populationTranscranial direct current stimulation (tDCS)Transcranial magnetic stimulation (TMS)Unilateral lesion

Identifiers

PMID26070517
PMCPMC5326549
OpenAlexW652900182

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.