ArticlePaediatric drugs2015
Comparison of Drug Utilization Patterns in Observational Data: Antiepileptic Drugs in Pediatric Patients.
Article in Paediatric drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Utilization of Antiseizure Medications in Women of Childbearing Age With Epilepsy and Nonepilepsy Indications: A Retrospective Cohort Study.Neurology · 2023Article
- Analysis of the prescription pattern of psychotropics in an outpatient department of a general hospital psychiatry unit.Medical journal, Armed Forces India · 2022Article
- Oxcarbazepine oral suspension in young pediatric patients with partial seizures and/or generalized tonic-clonic seizures in routine clinical practice in China: a prospective observational study.World journal of pediatrics : WJP · 2018Observational
- Antiepileptic drug use in Italian children over a decade.European journal of clinical pharmacology · 2017Article
- Properties of healthcare teaming networks as a function of network construction algorithms.PloS one · 2017Article
- Anti-epileptic drug utilisation in paediatrics: a systematic review.BMJ paediatrics open · 2017Article
- Causal inference as an emerging statistical approach in neurology: an example for epilepsy in the elderly.Clinical epidemiology · 2017Review
- Trends in Antiepileptic Drug Prescriptions for Childhood Epilepsy at a Tertiary Children's Hospital in Korea, 2001-2012.Paediatric drugs · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposePhysicians require information on the comparative benefits and harms of medications for optimal treatment decisions. However, this type of data is limited, especially for pediatric patients.
objectiveOur aim was to use observational data to measure and compare medication utilization patterns in a pediatric patient population.
methodsUsing pharmacy claims data from a large, national-scale insurance program in the USA, we identified all patients with a diagnosis of epilepsy treated with a first-generation antiepileptic drug (carbamazepine, ethosuximide, phenobarbital, phenytoin, or valproate) or a second-generation antiepileptic drug [carbamazepine extended release (XR), gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate, valproate XR, or zonisamide]. Treatment periods were defined on the basis of prescription fill dates and medication days supplied. Medication use was measured for individual antiepileptic drugs and for first-generation and second-generation drugs as groups.
resultsThere were 2527 patients (54 %) who initiated therapy with first-generation antiepileptics and 2139 patients (46 %) who initiated therapy with second-generation antiepileptics. First- and second-generation drugs had the same 1-year retention rates [26 % (95 % confidence interval (CI) 24-28) and 26 % (95 % CI 25-28), respectively], and 26 % of patients (95 % CI 25-28) and 29 % of patients (95 % CI 27-31) who started on a first- or second-generation antiepileptic medication, respectively, resumed treatment with the initial drug after discontinuation. Overall, 73 % of patients (95 % CI 71-74) were treated with only one antiepileptic drug, with similar rates for patients started on first- and second-generation drugs [71 % (95 % CI 69-73) versus 74 % (95 % CI 72-76)].
conclusionComparing drug utilization patterns in a pediatric population using observational data, we found similar rates of retention and therapeutic changes. These findings are consistent with the available comparative data and demonstrate an approach that could be extended to other drug classes and conditions in pediatric populations to examine drug effectiveness.
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