ArticlePloS one2015
Fatigue as a Driver of Overall Quality of Life in Cancer Patients.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Prevalence and Impact of Fatigue on Quality of Life (QOL) of Cancer Patients Undergoing Chemotherapy: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2023Pooled it
- Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Health-related quality of life with linvoseltamab treatment for relapsed/refractory multiple myeloma in LINKER-MM1.Blood neoplasia · 2026Trial
- Quality of life in cemiplimab-treated patients with locally advanced basal cell carcinoma in a Phase II clinical trial.Future oncology (London, England) · 2024Trial
- Identifying sleep disturbance- and fatigue-related factors of poor health-related quality of life in patients with advanced ovarian cancer.Journal of patient-reported outcomes · 2026Article
- Patient-reported outcome thresholds and their associations with survival, adverse events, and quality of life in a pooled analysis of breast cancer trials.International journal of cancer · 2025Article
- Patient-centered outcomes and preference between darolutamide and enzalutamide: insights from the ODENZA trial.Translational andrology and urology · 2025Article
- Factors associated with reduction in quality of life after SARS-CoV-2 infection.Scientific reports · 2025Article
- Fatigue in Prostate Cancer: A Roundtable Discussion and Thematic Literature Review.European urology open science · 2024Review
- Epigenomic Links Between Social Determinants of Health and Symptoms: A Scoping Review.Biological research for nursing · 2023Article
- Measuring Health-Related Quality of Life With Multimodal Data: Viewpoint.Journal of medical Internet research · 2022Article
- Which triggers could support timely identification of primary antibody deficiency? A qualitative study using the patient perspective.Orphanet journal of rare diseases · 2021Article
- Inflammatory Biomarkers, Hematopoietic Stem Cells, and Symptoms in Breast Cancer Patients Undergoing Adjuvant Radiation Therapy.JNCI cancer spectrum · 2020Article
- Willingness of women with early estrogen receptor-positive breast cancer to take adjuvant CDK4/6 inhibitors.Current oncology (Toronto, Ont.) · 2020Article
- Cancer-Related Fatigue and Muscle Quality in Hodgkin's Lymphoma Survivors.Integrative cancer therapies · 2018Article
- Factors Influencing Global Health Related Quality of Life in Elderly Cancer Patients: Results of a Secondary Data Analysis.Geriatrics (Basel, Switzerland) · 2018Article
- Increased Incidence of Fatigue in Patients with Primary Immunodeficiency Disorders: Prevalence and Associations Within the US Immunodeficiency Network Registry.Journal of clinical immunology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis manuscript describes an approach for analyzing large amounts of disparate clinical data to elucidate the most impactful factor(s) that relate to a meaningful clinical outcome, in this case, the quality of life of cancer patients. The relationships between clinical and quality of life variables were evaluated using the EORTC QLQ-C30 global health domain--a validated surrogate variable for overall cancer patient well-being.
methodsA cross-sectional study design was used to evaluate the determinants of global health in cancer patients who initiated treatment at two regional medical centers between January 2001 and December 2009. Variables analyzed included 15 EORTC QLQ-C30 scales, age at diagnosis, gender, newly diagnosed/ recurrent disease status, and stage. The decision tree algorithm, perhaps unfamiliar to practicing clinicians, evaluates the relative contribution of individual parameters in classifying a clinically meaningful functional endpoint, such as the global health of a patient.
findingsMultiple patient characteristics were identified as important contributors. Fatigue, in particular, emerged as the most prevalent indicator of cancer patients' quality of life in 16/23 clinically relevant subsets. This analysis allowed results to be stated in a clinically-intuitive, rule set format using the language and quantities of the Quality of Life (QoL) tool itself.
interpretationBy applying the classification algorithms to a large data set, identification of fatigue as a root factor in driving global health and overall QoL was revealed. The ability to practice mining of clinical data sets to uncover critical clinical insights that are immediately applicable to patient care practices is illustrated.
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