ArticleJournal of the American Chemical Society2015
Versatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Orthogonal nucleophile-ordered assembly for modular access to enantiopure 1,2-amino alcohols.Nature chemistry · 2026Article
- Trifluoromethylation-Induced Lactonization: A Novel Transformation of Unsaturated Carboxylic Acids.ChemistryOpen · 2026Review
- FeClChemistryOpen · 2026Article
- Copper-Catalyzed Asymmetric Amino Lactonization of Alkenes: Direct Access to Enantioenriched 1,2-Alkylamino Alcohol Derivatives.Journal of the American Chemical Society · 2026Article
- Uncovering outer-sphere mechanisms governing chemoselectivity in copper-photocatalyzed ATRA reactions of CFChemical science · 2026Article
- Copper-Catalyzed 1,2-Diazidation and 1,2-Azidooxygenation of 1,3-Dienes: Three Divergent Protocols Using Zhdankin's Reagent.The Journal of organic chemistry · 2025Article
- Enantioselective Alkoxycarbonyl-Lactonization of Alkenes via the Merger of Photoredox and Copper Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Directed Evolution of Copper-Substituted Nonheme Enzymes for Enantioselective Alkene Oxytrifluoromethylation.Journal of the American Chemical Society · 2025Article
- Enantioselective 3,4-Oxyamination of 1,3-Dienes Enabled by an Electron-Rich Planar Chiral Rhodium Indenyl Catalyst.Organic letters · 2025Article
- Asymmetric Aziridination of Allylic Carbamates Using Ion-Paired Rhodium Complexes and Extrapolation to C─H Amination of Phenethyl Carbamates.Angewandte Chemie (International ed. in English) · 2025Article
- Supramolecular Double-Helical Polymers: Supramolecular Chiral Induction and Asymmetric Catalysis.Molecules (Basel, Switzerland) · 2025Article
- Copper-Catalyzed Cyclization and Alkene Transposition Cascade Enables a Modular Synthesis of Complex Spirocyclic Ethers.Journal of the American Chemical Society · 2025Article
- Trifluoromethylative and Pentafluoroethylative Heterofunctionalization (C-O, C-S, and C-N) of Alkenes Using Visible Light Photocatalysis.ACS omega · 2024Article
- Access to Carbonyl Azides via Iodine(III)-Mediated Cross-Coupling.Organic letters · 2024Article
- Enhancing Electrocatalytic Semihydrogenation of Alkynes via Weakening Alkene Adsorption over Electron-Depleted Cu Nanowires.ACS nanoscience Au · 2024Article
- Stereoselective Fe-Catalyzed Decoupled Cross-Couplings: Chiral Vinyl Oxazolidinones as Effective Radical Lynchpins for Diastereoselective C(spACS catalysis · 2024Article
- Three-Component Radical Cross-Coupling: Asymmetric Vicinal Sulfonyl-Esterification of Alkenes Involving Sulfur Dioxide.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Intramolecular Carboxyamidation of Alkyne-Tethered O-Acylhydroxamates through Formation of Fe(III)-Nitrenoids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Enantioenriched Allylesters via a Copper-Catalyzed Diene Carboesterification with Alkyltrifluoroborates and Carboxylic Acids.The Journal of organic chemistry · 2024Article
- Azido-alkynylation of alkenes through radical-polar crossover.Chemical science · 2023Article
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2 authors.
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Abstract
A versatile method for the rapid synthesis of diverse enantiomerically enriched lactones has been developed based on Cu-catalyzed enantioselective radical oxyfunctionalization of alkenes. The scope of this strategy encompasses a series of enantioselective difunctionalization reactions: oxyazidation, oxysulfonylation, oxyarylation, diacyloxylation, and oxyalkylation. These reactions provide straightforward access to a wide range of useful chiral lactone building blocks containing tetrasubstituted stereogenic centers, which are hard to access traditionally.
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