ReviewAmerican journal of clinical and experimental urology2015
Mini-review: Does Notch promote or suppress cancer? New findings and old controversies.
Review in American journal of clinical and experimental urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Different Expression Levels of DLK2 Inhibit NOTCH Signaling and Inversely Modulate MDA-MB-231 Breast Cancer Tumor Growth In Vivo.International journal of molecular sciences · 2022Article
- PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation.Biomedicines · 2020Review
- Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer.Molecular medicine reports · 2017Article
- Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma.Oncotarget · 2017Article
- Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis.Cell death & disease · 2016Review
- Notch2 as a promising prognostic biomarker for oesophageal squamous cell carcinoma.Scientific reports · 2016Article
- Notch Signaling in Pancreatic Development.International journal of molecular sciences · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Notch signaling in tumorigenesis and cancer progression presents a certain enigma. Numerous experimental studies reported significant effects in cancer, yet of varying magnitude and opposite sign. This mini review is aimed to streamline our understanding of the Notch role in tumor progression, and outline future experiments to clarify the modality of Notch function and perspectives of the Notch-based anticancer treatments.
Indexed as
Identifiers
26069884PMC4446379What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.